高渗盐水雾化对婴幼儿喘息性疾病预后及生存质量的影响随访研究

Effect of hypertonic saline spray on the follow-up study in children with bronchiolitis in infants prognosis and quality of life

目的:探讨高渗盐水雾化对治疗婴幼儿喘息性疾病预后及生存质量的影响。方法:采用随机对照盲法,根据入院时间连续编号,用随机数字表法随机入组,共三组。所有患儿采用相似的其他综合治疗措施(抗感染、吸氧、维持水电解质酸碱平衡等),均予雾化吸入支气管扩张剂(0.5%沙丁胺醇+布地奈德3mL),同时所有患儿根据雾化药物的不同分为:(1)3%Nacl组4mL;(2)5%Nacl组4mL;(3)0.9%Nacl组4mL。采用前瞻性对照研究,比较三种不同药物雾化吸入治疗婴幼儿喘息性疾病的疗效及有效性和安全性。结果:A组的治疗总有效率为96.0%,显著高于B组(86.0%)与C组(84.0%),差异均具有统计学意义(P<0.05);A组喘息缓解时间、咳嗽缓解时间、住院时间及哮鸣音消失时间均少于B、C组,差异有统计学意义(P<0.05)。A组的不良反应发生率为0%,低于B组(16%)、C组(10%)。结论:3%高渗盐水雾化吸入用于治疗婴幼儿喘息性疾病可提升治疗效果,缩短喘息缓解时间、咳嗽缓解时间、住院时间及哮鸣音消失时间,减少不良反应,提高预后生存质量,具有临床推广意义。

Objective：To investigate the effect of hypertonic saline spray for the treatment of children with asthmatic disease prognosis and quality of life.Methods： 150 cases were randomly divided into A, B, C3 group, 50 in each. A group was given 3% hypertonic saline inhalation, group B given 5% hypertonic saline inhalation, group C given 0.9% saline inhalation. Comparison of the three groups of children with total effective lungs wheeze, lung auscultation disappear time, and the incidence of adverse reactions. Results：A treatment group total effective rate was 96.0%, significantly higher than group B （86.0%） and group C （84.0%）, the differences were statistically significant （P〈0.05）; A group remission time breathing, cough relief time , hospitalization and wheezing disappeared time were less than B, group C, the difference was statistically significant （P〈0.05）. A group of adverse events was 0%, lower than group B （16%）, group C （10%）. Conclusion：3% hypertonic saline inhalation for the treatment of asthmatic disease may enhance the therapeutic effect, shorten time to ease breathing, cough relief time, hospitalization and wheezing disappeared time, reduce the incidence of adverse reactions and improve the quality of patient survival, having clinical significance.