长期吸食甲基苯丙胺对免疫系统的影响

THE INFLUENCE OF IMMUNE FUNCTION IN CHRONIC METHAMPHETAMINE ADDICTS

目的:探索长期吸食甲基苯丙胺对机体免疫功能的影响。方法:采集51例长期吸食甲基苯丙胺患者(甲基苯丙胺组)的血样,检测其血常规、T淋巴细胞亚群(CD3^+、CD4^+、CD8^+、CD4^+/CD8^+)、B细胞(Bcell)、NK细胞(NK cell)、免疫球蛋白E(IgE)、免疫球蛋白G(IgG)、免疫球蛋白A(Ig A)、免疫球蛋白M(IgM)、补体C3、补体C4,并与53例健康体检者(正常对照组)进行比较。结果:甲基苯丙胺组CD3^+、CD4^+、CD4^+/CD8^+、B cell、NK cell、IgG、IgM、C3、C4较正常对照组降低,两者比较差异有统计学意义,两组之间CD8^+、IgE、Ig A差异无统计学意义。甲基苯丙胺组白细胞(WBC)、中性粒细胞(NEU)、中性粒细胞比率(NEU%)、淋巴细胞比率(LYM%)、血小板(PLT)较正常对照降低,差异具有统计学意义,两组淋巴细胞(LYM)、单核细胞(MON)、单核细胞比率(MON%)、红细胞(RBC)、血红蛋白(HGB)比较无统计学差异。结论:长期吸食甲基苯丙胺对免疫功能有不同程度的损害,甲基苯丙胺对机体免疫功能的抑制作用不仅作用于各种淋巴细胞,亦对某些血细胞有不同程度的抑制。

Objective：To investigate the influence of methamphetamine on immunologic function in drug abusers. Methods：The data from 51 cases of methamphetamine abusers（ methamphetamine group） and 53 participants who had physical examination （normal control group ） were collected, The T lymphocyte subsets cell（ CD3 ＋ , CD 4＋, CD 8 ＋ , CD 4 ＋/CD 8 ＋ ）, B cell, NK cell, IgE , IgG,IgA, IgM, C3 ,C4 and blood routine were detected. Results ：There were statistically significant differences in CD3 ＋ , CD4 ＋ ,CD4 ＋/ CD8 ＋ ,B cell, NK cell, IgG, IgM, C3, C4 , WBC, NEU, NEU% , LYM% between two groups, but the CD8 ＋ ,IgE,IgA,LYM, MON, MON% and RBC were not statistically significant between two groups. Conclusion： There are significant differences of impaired immunologic function in methamphetamine group compared with the normal control group. The influence of methamphetamine on immunologic function is not only applied to a variety of lymphocytes, but also for some blood cells.