致癌因子:长非编码RNA RoR

An oncogene:long noncoding RNA RoR

重编程调节因子RoR(regulator of reprogramming)是一类最近被鉴别出来的长非编码RNA。研究表明,长非编码RNA RoR不仅在多能干细胞的重编程过程中起着重要作用,而且对癌症等重大疾病的发生、发展产生重要影响。现围绕长非编码RNA RoR近几年的研究成果,总结了它在肝癌、乳腺癌、结肠癌、胰腺癌以及鼻咽癌等癌细胞生长、增殖、侵袭、转移和治疗抗性等方面的作用,同时,概述了长非编码RNA RoR对抑癌基因p53的负向调控作用。这些表明长非编码RNA RoR是一个致癌因子,它有可能成为癌症治疗的靶点。

Regulator of reprogramming （RoR） is a newly identified long noncoding RNA （lncRNA）. Studies have indicated that lncRNA RoR not only plays an important role in reprogramming, but also significantly affects the development of cancer. Based on recent research progress on lncRNA RoR, we summarized its effects on the growth, proliferation, invasion, migration and chemoresistance of the cancer cells of the liver, breast, colon, pancreat, nasopharynx, and so on. Its negative regulatory effect on tumor suppressor gene p53 is also included. These evidence strongly suggests that lncRNA RoR functions as an oncogenic lncRNA and may be as a cancer therapeutic target.