Cofilin在疾病中的研究进展

Research progress of cofilin in diseases

Cofilin是一种肌动蛋白结合蛋白,属于肌动蛋白解聚因子家族成员,普遍存在于真核细胞。它与肌动蛋白微丝(F-actin)结合,调节F-actin的解聚和重构。Cofilin具有多种生物学功能,如参与肌动蛋白骨架重组、核转运、胞质分裂以及心血管生成等。在应激条件下,cofilin可通过相应作用通路进行调节,改变细胞的功能。Cofilin在多种疾病如肿瘤、神经系统性疾病、血管性疾病、感染性疾病等的发生与发展中都起到了非常重要的作用。

Cofilin is a kind of actin-binding protein. It belongs to the family member of actin depolymerization factors which ubiquitously exists in eukaryotic cells. Cofilin byinds to actin flament （F-actin） and mediates the depolymerization and reorganization of F-actin. It has a variety of biological functions, such as involvement in the restructuring of actin cytoskeleton, nuclear transfer, cytokinesis as well as the formation of cardiovascular system and so on. Cofilin can mediate the function of the cells through the corresponding pathway with environmental stress. Cofilin plays a pivotal role in the occurrence and development of many kinds of diseases such as cancer, neurological diseases, vascular diseases, infectious diseases.