益气养阴汤应用于早期胃癌经腔镜微创术后对患者免疫功能及预后的影响

Impacts of Yiqi Yangyin Decoction on the Immune Function and Prognosis in the Patients after Endoscopic Minimally Invasive Surgery for Early Gastric Cancer

目的探讨益气养阴汤应用于早期胃癌经腔镜微创术后对患者免疫功能以及预后的影响。方法选取2011年2月至2013年3月收治的早期胃癌患者90例,随机将患者分为观察组和对照组各45例。两组患者在入院后均给予常规营养支持,并进行胃癌根治术的治疗,给予相应的对症治疗,对照组患者在术后留置胃管期间给予生理盐水,观察组患者给予益气养阴汤。观察两组患者治疗后病情复发率情况、手术前后相关指标(手术时间、术中出血量、术后肛门排气时间、术后住院时间、首次进食时间以及淋巴结清扫数目)以及T细胞亚群(CD3+、CD4+、CD8+、CD4+/CD8+)情况。结果观察组患者的手术时间、术中出血量、术后肛门排气时间、术后住院时间都明显的短于对照组,两组进行比较差异具有统计学意义(P<0.05);两组患者的首次进食时间以及淋巴结清扫数目进行比较差异无统计学意义(P>0.05)。两组患者治疗后,CD3+、CD4+和CD8+均有所下降,CD4+/CD8+均升高,两组比较差异具有统计学意义(P<0.05),说明观察组免疫功能改善优于对照组。治疗后观察组患者的疾病复发率为7.31%,低于对照组的22.5%,但两组比较差异无统计学意义(P>0.05)。结论益气养阴汤应用于早期胃癌患者中,可以增强患者的细胞免疫功能,改善患者预后。

Objective To discuss the impacts of yiqiyangyin decoction on the immune function and prognosis in the patients after endoscopic minimally invasive surgery for early gastric cancer. Methods From January 2011 to March 2013,90 patients of early gastric cancer were collected and randomized into an observation group and a control group,45 cases in each one. The routine nutrient support,the radical gastrectomy and corresponding symptomatic treatment were given in the two groups after admitted to hospital. In the control group,after surgery,the physical saline was given via postoperative indwelling gastric tube. In the observation group,yiqiyangyin decoction was given. The recurrence rate,the relevant indicators before and after surgery（ operative time,bleeding volume in operation,flatus time after surgery,admission duration after surgery,the time of first food intake and numbers of lymph node dissection） as well as T-cell subsets（ CD3^＋,CD4^＋,CD8^＋,CD4^＋/CD8^＋）. Results In the observation group,the operative time,bleeding volume in operation,flatus time after surgery,admission duration after surgery were shorter apparently than those in the control group,indicating the significant difference（ P〈0. 05）. The differences in the time of first food intake and numbers of lymph node dissection were not significant between the observation group and control group（ P〉0. 05）. After treatment,the levels of CD3^＋,CD4^＋and CD8^＋were reduced and CD4^＋/CD8^＋was increased in the two groups. The differences were significant between the two groups（ P〈0. 05）,indicating that the immune function in the observation group was improved better than that in the control group. After treatment,the recurrence rate was 7. 31% in the observation group,lower than 22. 5% in the control group,but without statistical significance in comparison（ P〉0. 05）. Conclusion Yiqiyangyin decoction strengthens the cellular immune function and improves the prognosis in the patients of early gastric cancer.