摘要
人组织激肽释放酶(kallikreins,KLKs)家族是一类结构具有高度同源性的丝氨酸蛋白酶,分布于各类组织中,其编码基因是人类基因组中最庞大的水解酶基因簇。随着对KLKs研究的不断深入,其在癌症发生发展过程中扮演的重要角色被逐步阐明,并在癌症预后与治疗方面具有重要价值。本文将对KLKs家族进行简单介绍,随后对KLKs在癌症发生与发展过程中的作用进行阐述。
Human tissue kallikreins (KLKs) are a class of serine proteases encoded by the largest protease gene cluster in human genome. KLKs play an important role in the development of cancer, and they are ex- pected as an effective target for cancer therapy. In this manuscript, we have reviewed the biochemical features of the KLKs family, as well as the involvement of KLKs in cancer development.
出处
《生命的化学》
CAS
CSCD
2017年第2期165-170,共6页
Chemistry of Life
基金
国家自然科学基金项目(81602743,C050103)
湖北省自然科学基金面上项目(2016CFB152)
湖北省教育厅项目(D20161204)
三峡大学基金项目(KJ2014B070,2015KZLO4)
关键词
组织激肽释放酶
增殖
迁移
侵袭
治疗靶点
Kallikrein-related peptidase
proliferation
migration
invasion
therapeutic targets