摘要
动脉粥样硬化是一种严重危害人类健康的疾病,其病程长,发病机制复杂,近来研究发现表观遗传机制在动脉粥样硬化的发生发展过程中起着重要的作用。TET2为一种DNA去甲基化酶,在表观遗传调控中扮演着重要的角色。研究表明,动脉粥样硬化斑块中TET2蛋白表达降低,TET2可能通过调节DNA甲基化从而影响动脉粥样硬化的发生发展。本综述旨在分析TET2和动脉粥样硬化之间关系的研究进展,进一步明确TET2在动脉粥样硬化发生发展中的作用及其作用机制,为动脉粥样硬化的有效防治提供新的思路和线索。
Atherosclerosis is a serious hazard to human health, which is a long course of disease and its un- derlying mechanisms are complex. Recently, an increasing number of reports suggested that epigenetic mech- anisms play important roles in the initiation and progression of atherosclerosis. Ten-eleven-translocation 2 （TET2） is a DNA demethyltransferase and plays an important role in epigenetic mechanism. Studies have showed that TET2 was downregulated in atherosclerotic lesions and involved in the pathophysiological pro- gression of atherosclerosis via DNA methylation modify. In this review, we discussed the progression of TET2 and atherosclerosis and further explored the role and potential mechanism on atherosclerosis. We aim to pro- vide new ideas and clues for effective prevention and treatment of atherosclerosis.
出处
《生命的化学》
CAS
CSCD
2017年第2期262-267,共6页
Chemistry of Life
基金
国家自然科学基金项目(81370378)
