四神丸对肾阳虚腹泻型肠易激综合征患者血清VIP、SP、5-HT3R水平的影响

Influence of Sishen decoction on VIP,SP and 5-HT3R levels of patients of diarrhea irritable bowel symptom with deficient kidney Yang

[目的]观察四神丸对肾阳虚腹泻型肠易激综合征(IBS-D)患者临床症状及血清VIP、SP、5-HT3R水平的影响。[方法]将50例符合纳入标准的患者随机分为对照组和治疗组,对照组为口服盐酸洛哌丁胺胶囊治疗,治疗组为四神丸汤剂治疗。主要观察指标有一周总排便次数、大便性状评分、临床症状积分、SAS评分、SDS评分、生活质量评分、检测血清VIP、SP、5-HT3R水平。观察指标共测定2次,基线期测定1次,治疗结束后测定1次。[结果]治疗组在患者大便性状评分、临床症状积分、SAS评分、生活质量评分、血清VIP、5-HT3R水平的改善方面要优于对照组,差异有统计学意义(P<0.05);治疗组在患者周大便次数、SDS评分、血清SP水平的改善方面与对照组相当,差异无统计学意义。[结论]四神丸能在一定程度上改善肾阳虚IBS-D患者的临床症状以及血清VIP、SP、5-HT3R水平,有较好的临床使用价值。

[Objective] To observe the influence of Sishen Decoction on VIP,SP and 5-HT3R levels of patients of deficient kidney Yang diarrhea irritable bowel symptom（IBS-D）. [Methods] Fifty patients of IBS-D were randomly divided into control group and treatment group. The control group was treated with oral loperamide hydrochloride capsules and the treatment group with Sishen decoction. Weekly defecation times,assessing scores of defecate, accumulated scores of clinical symptoms, SAS score, SDS score, life quality score,levels of VIP,SP and 5-HT3R of tested serum were observed detected two times,the baseline and the post-treatment. [Results]The treatment group was superior to the control group regarding to the improvement of score of defecate, accumulated scores of clinical symptoms, SAS score, life quality score and levels of VIP and 5-HT3R and the difference was statisticaly significant（P^0.05）. The treatment group was similar to the control group regarding to the improvement of weekly defecation times, SDS score and SP level and the difference has no statistical significance. [Conelusion]Sishen decoction can improve clinical symptoms as well as VIP,SP and 5-HT3R levels of IBS-D patients of deficient kidney Yang and has high clinical application value.