长链非编码RNA SNHG7在胃癌组织中的表达及其临床意义

Expression of long non-coding RNA SNHG7 in gastric carcinoma and its clinical significance

[目的]了解长链非编码RNA SNHG7在胃癌组织中的表达情况,并探讨其相关临床意义。[方法]采用实时荧光定量PCR(qRT-PCR)法检测SNHG7在82例胃癌患者癌和癌旁组织表达情况,χ2检验分析胃癌组织中SNHG7表达量与临床病理参数相关性;应用Log-rank检验和COX回归模型分析胃癌组织中SNHG7表达量与胃癌患者术后预后的关系。[结果]SNHG7在胃癌组织中较癌旁组织表达明显升高(P<0.001);胃癌组织中SNHG7的表达水平与SNHG7的表达与肿瘤的浸润深度(P<0.001),临床分期(P=0.003)、区域淋巴结转移有关(P=0.035)。胃癌组织中SNHG7相对高表达与患者术后无瘤生存期显著缩短(20.4个月vs.28.8个月,P=0.001)。胃癌组织中SNHG7高表达是影响胃癌患者术后无瘤生存期的一个独立危险因素(HR=2.067;95%CI 1.012~4.219;P=0.046)。[结论]SNHG7有望成为预测胃癌患者术后预后的一个新的潜在标记物。

[Objective]To investigate the expression of the long non-coding RNA SNHG7 in gastric carcinoma（GC） and its clinical significance. [Methods]The real time fluorescence quantitative PCR（qRT-PCR） was performed to detect the expression difference of SNHG7 between GC and its adjacent normal tissue. Then,the correlation between the expression of SNHG7 in GC and the clinicopathological character- istics was analyzed by Chi-square test. Moreover, the potential of SNHG7 in predicting the prognosis of pa, tient with GC after operation was assessed by Log-rank test and Cox^s proportional hazards regression model. [Results]The expression of SNHG7 in GC was markedly higher than that in its adjacent normal tis- sue（P^0. 0001）. Moreover, the expression of SNHG7 in GC was significantly correlated with invasion depth（P%0. 001） ,advanced TNM stage（P=0. 003）and lymph nodes metastasis（P=0. 035）. The patients with higher expression of SNHG7 in GC had a statistically shorter tumor-free survival time（20.4 months vs. 28. 8 months,P=0. 001）. [Conclusion]SNHG7 may be a new prognostic biomarker for GC.