微创切除术联合低剂量放疗对早期喉癌治疗效果的研究

The effect of minimally invasive resection combined with low-dose radiation on early laryngeal cancer

目的探究微创切除术联合低剂量放疗对早期喉癌治疗效果的影响。方法选取早期喉癌患者60例,依据抽签法将患者分为治疗组及对照组,每组各30例。治疗组患者给予支撑喉镜下微创手术联合低剂量放疗进行治疗;对照组患者给予支撑喉镜下微创手术治疗;观察比较两组患者治疗后出现咽部干燥、呼吸困难、咯血、嗅觉减退情况及发音功能、复发转移情况、平均生存时间及累积生存率。结果术后两组患者咽部干燥、呼吸困难、咯血、嗅觉减退发生率比较,差异无统计学意义(P﹥0.05),治疗组患者发音功能差于对照组(P﹤0.05);随访截至2016年8月,治疗组患者疾病无进展时间优于对照组,差异有统计学意义(P﹤0.05),两组患者的平均生存时间及累积生存率比较,差异无统计学意义(P﹥0.05)。结论微创切除术联合低剂量放疗相对于单纯微创切除术可减少早期喉癌患者的复发转移情况,但对患者的平均生存时间及累积生存率无明显影响。

Objective To explore the effect of minimally invasive resection combined with low-dose radiation on the early laryngeal cancer. Method 60 patients with early laryngeal cancer were enrolled in the study, then were randomized as study group （n=30） or control group （n=30）. Laryngoscope-guided minimally invasive surgery （M/S） combined with low-dose radiation or MIS alone were administered in study group and control group, respectively. The pharyngeal dry- ness, dyspnea, hemoptysis, hyposmia, phonatory function, as well as 1-year recurrence and metastasis, mean survival time and cumulative survival rate of the two groups were compared. Result There was no significant difference in the in- cidence of phmyngeal dryness, dyspnea, hemoptysis and hyposmia between the two groups （P〉0.05）, but the study group had worse phonatory function than the control group （P〈0.05）. In follow up as of Aug 2016, the PFS was significantly better in study group than control group （P〈0.05）. While the mean stuwival time and cumulative survival rate were similar between the two groups （P〉0.05）. Conclusion Minimally mvaswe resection combined with low-dose radiation can sig- nificantly reduce the recurrence and metastasis in patients with early laryngeal cancer, with no benefit regarding mean sur- vival time and cumulative survival rate.