普萘洛尔对婴幼儿血管瘤患者尿液中基质金属蛋白酶(MMPs)表达水平的影响

Effect of propranolol on the expression of matrix metalloproteinase in the urine of infantile hemangioma patients

目的通过分析普萘洛尔对婴幼儿血管瘤(IH)患儿尿液中MMP-9及MMP-2水平的影响,探讨普萘洛尔治疗IH的疗效及可能作用机制。方法对治疗组18例IH患儿给予口服盐酸普萘洛尔治疗,剂量为1.0~1.5 mg/kg,1次/d,疗程为4~8个月。设置未服药组为对照组,对比分析两组患儿在治疗前,治疗后1、3个月尿液中基质金属蛋白酶-2(MMP-2)及基质金属蛋白酶-9(MMP-9)表达水平。结果(1)治疗组18例患儿经口服普萘洛尔治疗后,血管瘤的生长得到了抑制,瘤体体积显著缩小,瘤体表面颜色变黯淡,且张力大小明显减弱;(2)治疗前,两组患儿尿液中MMP-2与MMP-9差异均无统计学意义(P±0.05);治疗后第1、3个月时,两组患儿尿液中MMP-2和MMP-9差异均有统计学意义(P<0.05)。结论普萘洛尔治疗IH是通过下调患儿尿液中MMP-9及MMP-2的水平而发挥作用,是普萘洛尔治疗IH的作用机制之一。

Objective To explore the effect and mechanism of propranolol by analyzing the level of MMP-9 and MMP-2 in the urine of infantile hemangioma （IH） patients.Methods Oral propranolol was administered in 18 IH patients in the treatment group.The dose was 1.0～1.5 mg/kg once per day for 4 to 8 months.The untreated IH patients served as the control group.The level of MMP-2 and MMP-9 in the urine of both groups was compared and analyzed before treatment as well as 1 month and 3 months after treatment.Results （1） The growth of hemangiomata was inhibited in the treatment group after oral propranolol.Inhibition of gTowth mainly manifested in significantly reduced tumor volume,fading of color on the tumor surface,and significantly decreased tension.（2） The is no statistical difference in the level of expression of MMP-2 and MMP-9 in the urine between the two groups before treatment （P〉0.05）.One month and 3 months after treatment,the level of expression of MMP-2 and MMP-9 in the urine between the two groups shows significant difference （P〈0.05）.Conclusion Propranolol may exert an effect by down grading the level of MMP-9 and MMP-2 in the treatment of IH.It is one of the mechanisms of propranolol in the treatment of IH.