醛酮还原酶的研究进展

The Research Progress of Aldo Keto Reductase

文章综述了醛酮还原酶的研究进展。醛酮还原酶(AKRs)是氧化还原酶超家族成员之一,目前已知有16个家族,超过190个家族成员,AKRs成员均属于单体胞质蛋白,以还原型烟酰胺腺嘌呤二核苷酸磷酸(NADPH)作为其辅酶,将醛酮类化合物还原成相应的醇类。近年来相关研究证实AKRs与多种疾病密切相关,因此,了解醛酮还原酶与多种疾病的关系意义重大。

Aldo keto reductase （AKRs） is an oxidoreductase supeffamily. As far as we know,it embraces 16 families and more than190 family members. AKRs members are single cytoplasmic proteins ,including nicotinamide adenine dinueleotide phosphate （NADPH）as its eoenzyme;aldehyde and ketone compounds will be reduced to the corresponding alcohols. Recent studies have confirmed thatAKRs are closely related with many diseases. The role of AKRs in various diseases has been reviewed.