摘要
为探讨麦冬对实验性2型糖尿病大鼠的保护作用,该研究采用高脂饲料喂养联合低剂量链脲佐菌素(STZ)诱导的实验性2型糖尿病大鼠模型,观察麦冬提取物对大鼠血糖、口服葡萄糖耐受、胰岛素抵抗、肌糖原、肝糖原、尿蛋白、肾脏指数及胰腺病理损伤的影响。结果显示,麦冬提取物能显著降低2型糖尿病的血糖、减少口服葡萄糖耐量实验的曲线下面积;能显著提高大鼠对外源胰岛素的敏感性及肝糖原含量、骨骼肌糖原含量;能显著降低肾指数及尿蛋白排泄率;并抑制胰腺的组织病理损伤。综上所述,麦冬提取物对实验性2型糖尿病大鼠具有显著保护作用。
The aim of the present study is to investigate the protective effects of Ophiopogonis japonicus extract on experimental type 2 diabetic rats. The high-fat diet and low-dose streptozotocin （STZ） -in- duced type 2 diabetic model in rats was used to observe the effect of Ophiopogonis japonicus extract on blood glucose level, oral glucose tolerance, insulin sensitivity, glycogen content in liver and skeletal muscle, urinary protein excretion and histopathological changes of pancreas. Results showed that Ophio- pogonis japonicus extract could significantly lower the blood glucose levels and the AUCs during oral glu- cose tolerance test, improve insulin sensitivity, increase glycogen contents in liver and skeletal muscle, reduce urinary protein excretion, lower the kidney weight/body weight ratio and alleviate histopathological changes of pancrea occurred in diabetic rats by comparison with untreated diabetic rats. In conclusion, Ophiopogonis japonicus extract exerts remarkable protective effects in experimental type 2 diabetes melli- tus, thus justifying its traditional usage.
出处
《中山大学学报（自然科学版）》
CAS
CSCD
北大核心
2017年第3期119-124,共6页
Acta Scientiarum Naturalium Universitatis Sunyatseni
基金
广东省重大科技专项项目(2013A022100022)
广州市科技计划项目(201704020119)
关键词
麦冬
2型糖尿病
保护作用
Ophiopogonis japonicus
type 2 diabetes meIlitus
protective effect
