妊娠期高血压疾病患者血浆生长分化因子-15水平的测定及临床意义

Determination and clinical significance of plasma growth differentiation factor-15 in hypertensive disorders complicating pregnancy

目的探讨孕妇血浆生长分化因子-15(plasma growth differentiation factor-15,GDF-15)在妊娠期高血压疾病中的预测和诊断价值。方法选择2014年7月至2016年6月在海门市人民医院就诊及住院分娩的妊娠期高血压疾病孕妇137例,包括妊娠期高血压61例,轻度子痫前期28例,重度子痫前期27例,慢性高血压21例。另有同期在我院产前检查及住院分娩的正常单胎孕妇120例。所有正常孕妇及各组妊娠期高血压疾病孕妇分别按孕20周前、20~27周、28~35周、36周后再分组并测定GDF-15比较分析。结果子痫前期组GDF-15水平高于妊娠期高血压组、慢性高血压组以及正常孕妇组,重度子痫前期组高于轻度子痫前期组,差异均有统计学意义(P<0.05)。重度子痫前期组中,孕36周后组GDF-15水平显著高于孕20周前组、20~27周组、28~35周组,差异有统计学意义(P<0.05);轻度子痫前期组、妊娠期高血压组、慢性高血压组各孕期GDF-15水平差异无统计学意义(P>0.05)。结论 GDF-15可能是妊娠期高血压疾病严重程度的潜在预测因子。

Objective To discuss the predictive and diagnostic value of plasma growth differentiation factor - 15 （ GDF - 15 ） in women with hypertensive disorders complicating pregnancy. Methods 137 women with hypertensive disorders complicating pregnancy including 61 gestational hypertension, 28 mild preeclampsia, 27 severe preeclampsia and 21 chronic hypertension complicating pregnancy hospitlized in Haimen People＇s Hospital from July 2014 to June 2016 were collected. They were divided into four groups according to severity of disease. 120 normal pregnant women were collected over the same time as the control group. Testing the plasma GDF - 15 in all women. Then, every group were further divided into 4 groups according to different gestational age as less than 20 weeks ,20 -27 weeks,28- 35 weeks and more than 36 weeks. Results Plasma GDF - 15 in preeclampsia group was significantly higher than other groups. Among them the severe group was higher than the mild group（P 〈0. 05）. GDF - 15 in the gestational age more than 36 weeks group was significantly higher than that in gestational age less than 20 weeks, 20 - 27weeks and 28 - 35weeks groups in severe preeclampsia pregnant（P 〈0. 05）. There were no differences in other groups throughout the pregnancy（P 〉0. 05）. Conclusion GDF - 15 maybe a potential predictor of severity in hypertensive disorders complicating pregnancy.