基于化学小分子探针的信号转导过程研究进展

Progress report on investigations on signal transduction processes utilizing small chemical probes

本文综述了国家自然科学基金委员会"基于化学小分子探针的信号转导过程研究"重大研究计划的系统研究成果。重点涵盖了在"针对信号转导过程的新型分子探针的开发与制备"、"探测信号转导过程的化学生物学方法与前沿技术"、"信号转导分子机制的深入研究"和"基于信号转导途径的药物靶标与先导化合物发掘"等4个方面所取得的突破性创新进展。简要展望了化学生物学发展态势与前景,特别是应当继续发挥学科交叉的优势,在工具发展和技术革新上实现新飞跃,开辟生命科学研究前沿新方向。

This article reviewed the progress of the Major Research Plan by National Natural Science Foun- dation of China entitled ＂Investigations on Signal Transduction Processes Utilizing Small Chemical Probes＂. Major achievements and breakthroughs are summarized in the following four areas. ＂Generation of chemical probes for studying signal transduction＂, ＂Development of new techniques and methods for detecting the information of signaling processes＂, ＂Molecular mechanisms of signal transduction based on small chemical probes＂ and ＂Target and lead discovery based on signal transduction processes＂. The future direction and perspective of chemical biology is briefly discussed, particularly on how to take advantage of the interdisciplinary research to further promote tool development and technology innovations, as well as to open new areas at the frontier of life sciences.