苍术及其有效成分对心血管和代谢系统药理作用的研究进展

Reseach Advances in Pharmacologic Actions of Atractylodis Rhizoma and Its Effective Components on Cardiovascular and Metabolic Systems

苍术及其有效成分具有降低高血糖、高血尿酸、高血压以及保护心肌的作用;其降低心房收缩频率的作用被临床用于治疗窦性心动过速。苍术及其有效成分能抑制抗利尿激素的释放,下调水通道蛋白(AQP)的表达,抑制Na^+/K^+-ATP酶的活性,产生利尿作用。苍术及其有效成分具有促进成骨细胞的增殖,发挥抗佝偻病和抗骨质疏松的效应。综述苍术及其有效成分对心血管和代谢系统药理作用的文献资料,并对其研究进展作了分析。

Rhizoma Atractylodis and its effective components have antihyperglycemic, anti-hyperuricemic, and anti-hypertensive effects, and displaying myocardial protection. Atractylodis Rhizoma and its effective components decrease- atrial contraction frequency, and are efficacious on treating sinus tachycardia in clinic. Atractylodis Rhizoma and its effec- tive components inhibit release of antidiuretic hormone, and down-regulate expression of aquaporin（water channel pro- teins）, as well as inhibit Na~/K＋-ATPase activity, and induce diuresis. Rhizoma Atractylodis and its effective components improve osteoblast proliferation, and may produce efficacy against rickets and osteoporosis. The literature of pharmaco- logic actions of cardiovascular and metabolism system in Rhizoma Atractylodis and its effective components, and its re- seach advances were analyzed.