2型糖尿病患者血清胆红素水平与踝肱指数的相关性分析

Correlative analysis of serum bilirubin level and ankle-brachial index in type 2 diabetic patients

目的探讨2型糖尿病患者血清胆红素水平与踝肱指数(ankle-brachial index,ABI)的相关性。方法 152例2型糖尿病患者根据ABI值分为外周动脉疾病(peripheral arterial disease,PAD,ABI≤0.9)组74例和非PAD组(0.9<ABI≤1.3)78例,比较两组年龄、性别、病程、血压(收缩压SBP,舒张压DBP)、体重指数(BMI)、糖化血红蛋白(HbA1c)、空腹及餐后2 h胰岛素(FINS、2 hINS)、空腹及餐后2 hC肽(FC-P,2 hC-P)、总胆红素(TBIL)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)水平的差异。结果两组间年龄、病程、SBP、DBP、HbA1c、ABI、TBIL、TC、LDL-C差异有统计学意义(P<0.05),两组间性别、BMI、FINS、2 hINS、FC-P、2 h C-P、TG、HDL-C差异无统计学意义(P>0.05)。相关分析显示,ABI与TBIL呈正相关(P<0.001);ABI与年龄、病程、SBP、DBP、HbA1c、LDL-C呈负相关(P<0.05);ABI与BMI、TC、TG、HDL-C、FINS、2 hINS、FC-P,2 hC-P无相关性(P>0.05)。二元Logistic回归分析显示年龄、病程、HbA1c、TBIL是PAD发生的独立危险因素(P<0.05)。结论血清胆红素水平与PAD的发生发展有关。

Objective To investigate the correlation between serum bilinlbin level and ankle-brachial index （ABI） in patients with type 2 diabetes mellitus. Methods 152 patients.with type 2 diabetes mellitus were divided into peripheral arterial disease （PAD, ABI≤0.9） group（n=74） and non-PAD group （0.9〈ABI≤1.3） （n=78） according to ABI value. The differences in age, sex, course of disease, blood pressure （systolic blood pressure, SBP, and diastolic blood pressure, DBP）, body mass index（BMI）, glyeosylated hemoglobin （HbAlc）, fasting and postprandial 2h insulin （FINS, 2 bINS）, fasting and postprandial 2 hC peptide （FC-P, 2hC-P）, total bilirubin （TBIL）, total cholesterol （TC）, triglyceride （TG）, high density lipoprotein cholesterol（HDL-C） and low density lipoprotein cholesterol （LDL-C） between the two groups were compared. Results There were significant differences in the age, course of disease, SBP, DBP, HbAlc, TBIL, TC and LDL-C between the two groups （P〈0.05）. The were no significant differences in the sex, BMI, FINS, 2hINS, FC-P, 2hC-P, TG and HDL-C between the two groups （P〉0.05）. Correlation analysis showed that ABI was positively correlated with TBIL（P〈0.001） and was negatively correlated with age, course of disease, SBP, DBP, HbAlc and LDL-C（P〈0.05）. And there was no correlation between ABI and BMI, TC, TG, HDL-C, FINS, 2 hINS, FC-P, 2 hC-P（P〉0.05）. Binary logistic regression analysis showed that age, course of disease, HbAlc, TBIL were independent risk factors for PAD（P〈0.05）. Conclusion Serum bilirubin level is associated with the development of PAD.