GLUT4调节ZAG改善胰岛素抵抗的研究

Study on the effect of GLUT4 in regulating ZAG to improve insulin resistance

胰岛素抵抗(insulin resistance,IR)是指胰岛素的靶细胞或者组织对生理浓度的胰岛素反应或者敏感性降低的一种病理状态,其中这些靶组织包括骨骼肌、脂肪组织、肝脏等,是引起代谢紊乱如代谢综合征、肥胖、高血压、高血脂、高尿酸血症以及糖尿病的重要因素。最近发现锌α2糖蛋白(zinc-α2-glycoprotein,ZAG)——一种新型脂肪因子具有改善胰岛素抵抗的作用。而葡萄糖转运体4(Glucose transporter 4,GLUT4)是改善胰岛素抵抗的公认物质之一,GLUT4表达途径在ZAG改善胰岛素抵抗中作用的研究有助于胰岛素抵抗机制的探索,并且为胰岛素抵抗相关疾病提供靶向治疗的依据。

Insulin resistance（IR） refers to a pathological state that the response or sensitivity of insulin target cells or tissues to the physiological concentration of insulin reduced. And these target tissues include skeletal muscle, adipose tissue, liver, etc., and are important factors that cause metabolic disorders such as metabolic syndrome, obesity, high blood pressure, hyperlipidemia, hyperuricemia and diabetes. Recently, zinc α2-glycoprotein（ZAG）, a novel adipokine, has been found to have an effect of improving insulin resistance. Glucose transporter 4（GLUT4） is one of the most important substances in the improvement of insulin resistance. The study of the role of GLUT4 expression pathway in ZAG improving insulin resistance contributes to the exploration of insulin resistance mechanism and provides the basis of targeted treatment for insulin resistance related diseases.