中医阴阳序贯疗法联合激素治疗卵巢早衰临床疗效的Meta分析

Meta-analysis of curative effect on sequential method of Yin and Yang adjustment combined with hormonal replacement therapy for premature ovary failure

目的评价中医阴阳序贯疗法联合激素治疗卵巢早衰的临床疗效。方法检索1989年1月—2017年1月清华同方中国期刊全文数据库、维普中文科技期刊全文数据库、万方数据库中关于中医阴阳序贯疗法联合激素治疗卵巢早衰临床疗效的随机对照研究的相关文献。参照Jadad评分量表对纳入的文献进行方法学质量评价,利用Review Manager5.3进行Meta分析,P<0.05为差异有统计学意义。结果共7篇文献纳入本研究,中医阴阳序贯疗法联合激素治疗卵巢早衰在总有效率、Kupperman评分变化、雌二醇(Estradiol,E_2)水平的变化及卵泡刺激素(follicle-stimulating hormone,FSH)水平的变化方面均明显优于单纯激素替代疗法,差异均有统计学意义(均P<0.05)。结论中医阴阳序贯疗法联合激素治疗卵巢早衰的临床疗效确切,但由于纳入研究的文献数量偏少,质量偏低,仍需要更多高质量、多中心、大样本的临床随机对照实验研究加以验证。

Objective To evaluate the curative effect on sequential method of Yin and Yang adjustment combined with hormonal replacement therapy in the treatment of premature ovary failure（POF）. Methods Ramdomized and controlled trials（RCT） papers published form January 1989 to January 2017 were searched in China academic journal, chongqing VIP and wanfang da- tabase. Jadad scale was used to devalue the quality papers. Meta-analusis was conducted by using RevMan 5.3, P〈0.05 was con- sidered statistically significant. Results 7 RCT papers were included after screening. Meta-analysis show the total efficacy rate, the Kupperman grade and the level of hormone（E2. FSH） of treatment group with sequential method of Yin and Yang adjustment combined with hormonal replacement therapy were higher than the hormonal replacement therapy control group（all P〈O.05）. Con- clusion Sequential method of Yin and Yang adjustment combined with hormonal replacement therapy has the marked effect to treat the POF. However, due to the lower and less quality of literatures, the high quality,large sample and muhicenter RCT should be carried to support it.