摘要
随着年龄增加，视网膜神经节细胞（retinal ganglion cells，RGC）会出现非病理性丢失、轴突变薄，其中RGC的改变为树突减少，而数量保持稳定；青光眼也会出现弥漫性和局部性RGC凋亡及轴突丢失。相干光断层扫描（optical coherence tomography，OCT）可以间接反映RGC及其轴突的改变，可鉴别年龄相关性和青光眼性RGC改变。在20～50岁年龄相关性改变对OCT检测的结果影响很小，OCT参数的进行性改变提示青光眼进展；50岁以上者年龄相关性改变出现，与功能损害一致的局部OCT参数改变提示青光眼进展。
Retinal ganglion cells （RGCs） and their axons lost with a non-pathological way during aging. Age-related changes were characterized by the loss of RGCs＇ dendrites, but the number of RGCs keeps stable. While glaucomatous changes show overall and focal RGCs reduction. Optical coherence tomography （OCT） can reflect the RGCs and their axons indirectly, which can differentiate between age-related and glaucomatous changes. Progressive OCT parameters change between 20-50 years indicated glaucoma injury because age-related changes have little effect on OCT parameters in this period. Age-related changes appear beyond 50 years when function related focal OCT parameters change indicated glaucoma progression.
出处
《国际眼科纵览》
2017年第2期87-91,共5页
International Review of Ophthalmology
基金
首都医科大学附属北京同仁医院科研基金（2015-YJJ-ZZL-011）
