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重复经颅磁刺激对首发精神分裂症患者血清脑源性神经营养因子的影响 被引量:4

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摘要 目的探讨重复经颅磁刺激治疗对首发精神分裂症患者血清脑源性神经营养因子(BDNF)的影响。方法将102例首发精神分裂症患者纳入本次研究,按照随机数表分为对照组和试验组,分别实施常规治疗和重复经颅磁刺激治疗。观察2组治疗前后BDNF1、BDNF2和BDNF3水平变化、治疗前后精神分裂症阳性和阴性症状量表评分及临床疗效。结果治疗后2组各项因子水平均较治疗前显著升高(P<0.05),试验组血清BDNF1、BDNF2和BDNF3水平均远高于对照组(P<0.05);治疗后试验组各量表评分显著低于对照组(P<0.05);总有效率显著高于对照组(P<0.05)。结论首发精神分裂症患者中采用重复经颅磁刺激治疗能够显著改善BDNF水平,减轻症状疗效改善显著。
出处 《中国实用神经疾病杂志》 2017年第10期68-70,共3页 Chinese Journal of Practical Nervous Diseases
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  • 1陈建洪,李长安.精神分裂症认知功能相关问题的研究进展[J].现代中西医结合杂志,2007,16(18):2623-2625. 被引量:4
  • 2Iritani S, Niizato K, Nawa H, et al. Immunohistochemical study of brain-derived neurotrophic factor and its receptor, TrkB in the hippocampal formation of schizophrenic brains [ J ]. Prog Neuropsychopharmacol Biol Psychiatry, 2003,27 ( 5 ) : 801-807.
  • 3Hashimoto T, Bergen SE, Nguyen QL, et al. Relationship of brainderived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia [ J ]. J Neurosci ,2005,25 (2) :372-383.
  • 4Huang TL, Lee CT. Associations between serum brain-derived neurotrophic factor leves and clinical phenotypes in schizophrenia patients [ J ]. J Psychiatr Res, 2006,40 ( 7 ) : 664-668.
  • 5Barde YA, Edgar D, Thoenen H. Purification of a new neurotrophic factor from mammalian brain [ J ]. EMBO J, 1982,1 (5) :549-553.
  • 6Angelucci F, Brene S, Mathe AA. BDNF in schizophrenia, depression and corresponding animal model [ J ]. Mol Psychiatry ,2005,10(4 ) :345-352.
  • 7Toyooka K, Asama K, Watanabe Y, et al. Decreased levels of brain-derived neurotrophic factor in serum of chronic schizophrenic patients [ J ]. Psychiatry Res, 2002,110 : 249-257.
  • 8Tan YL,Zhou DF,Cao Ly,et al. Decreased BDNF in serum of patients with chronic schizophrenia on long-term treatment with antipsychotics[ J]. Neuroscience Letters,2005,382:27-32.
  • 9Jockers S MC, Ren tzsch J, Danker I-IH,et al. Adequate antipsy chotic treatment normalizes serum nerve growth factor concentrations in schizophrenia with and without cannabis or additional substance abuse [ J ]. Neuroscience Letters, 2006, 400 : 262-266.
  • 10Angelucci F, Brene S, Mathe AA. BDNF in schizophrenia, depression and corresponding animal models [ J ]. Molecular Psychiatry, 2005,10:345-352.

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