小檗碱对AIS患者血清MIF和MONO%的调控作用

REGULATING EFFECTS OF BERBERINE ON SERUM MIF AND MONO% LEVEL OF AIS PATIENTS

目的:探讨小檗碱对急性缺血性脑卒中患者(AIS)血清巨噬细胞移动抑制因子(MIF)和单核细胞比率(MONO%)的调控作用。方法:120例AIS患者随机分为小檗碱组(n=60)和常规组(n=60),常规组仅给予常规治疗,小檗碱组在常规组治疗的基础上加用小檗碱口服(0.3g,日三次)。所有患者均检测入院第1天、14天时血清MIF、MONO%水平。结果:小檗碱组、常规组入院第1天MIF、MONO%比较差异无统计学意义(P>0.05)。两组第14天时的MIF、MONO%均明显低于本组第1天(P<0.05);并且,小檗碱组第14天时的MIF、MONO%明显低于常规组第14天(P<0.05)。结论:小檗碱可显著降低缺血性脑卒中急性期患者血清MIF和MONO%水平,抑制炎症反应。

Objective： To investigate the regulating effects ofberberine on serum macrophage migration inhiboition factor （MIF） and monocytes ratio （MONO%） level of acute ischemic stroke （AIS） patients. Methods： 120 AIS patients were randomly divided into routine trealrnent group and berberine group with 60 patients ha each group. The patients in routine treatment group were given routine treatment; While the patients in berberine group were also given berberine （0.3g, tid） on basis of routine treatment. The serum MIF and MONO% level of patients were respectively detected on the 1st and 14th day in hospital. Results： There was no statistically significant difference about senun MIF and MONO% level of patients on the 1st day in hospital between routine treatment group and berberine group （P〉0.05）. The serum MIF and MONO% level of patients in 2 group on the 14th day were obviously lower than the 1st day （P〈0.05）; Moreover, the senun MIF and MONO% level of patients in berberine group on the 14th day were obviously lower than routine treatment group on the 14th day（P〈0.05）. Conclusions： Berberine can obviously decrease the serum MIF and MONO% level orAlS patients, and in- hibit intlammatory response.