寻常型银屑病患者血清S100A12水平的测定及临床意义

Expression and clinical significance of serum S100A12 in patients with psoriasis vulgaris

目的了解寻常型银屑病患者血清中S100A12水平及其临床意义。方法 ELISA法检测50例寻常型银屑病患者和50例健康对照组血清S100A12水平,并计算患者银屑病面积和严重程度指数(psoriasis area and severity index,PASI)。使用Pearson分析法分析S100A12水平与PASI相关性。结果寻常型银屑病组血清S100A12水平为(154.4±114.9)ng/mL;对照组血清S100A12水平为(72.6±62.8)ng/mL。寻常型银屑病组S100A12水平高于对照组,差异有统计学意义(P<0.05)。Pearson分析结果显示寻常型银屑病组S100A12水平与PASI评分之间呈正相关性(r=0.436,P<0.05)。结论银屑病患者血清S100A12水平明显高于健康人,与疾病严重程度相关,可作为判断银屑病严重程度的指标。

Objective To understand the serum level and clinical significance of S100A12 in patients with psoriasis vulgaris. Methods Serum S100AI2 levels in 50 patients with psoriasis vulgaris and 50 normal controls were measured by ELISA. The psoriasis area and severity index （PASI） were assessed. Pearson correlation analysis was used to detect the correlation between $100Al2 level and PASI. Results The mean level of serum S100A12 in the psoriasis group was （154.4＋ 114.9） ng/mL, which was significantly higher than （72.6 ＋62.8） ng/mL in the control group （P〈0.015）. Pearson correlation analysis showed there was a positivity correlation between S100A12 levels and PASI scores in the psoriasis group （r =0.436, P〈 0.05）. Conclusion The level of S100A12 in psoriasis patients is significantly higher than that of the healthy people, which has the relationship with the severity of the disease and can be used as an indicator of the severity of psoriasis.