Faecalibacterium prausnitzii与人类疾病关系的研究进展

The relation between Faecalibacterium prausnitzii and human diseases:Research progress

Faecalibacterium prausnitzii(F.prausnitzii)是定植于哺乳动物胃肠道中的共生菌,同时也是健康成人肠道菌群中最丰富的细菌之一。本研究主要对F.prausnitzii与人体代谢性疾病如肥胖、糖尿病及宿主的消化道疾病如炎症性疾病、结肠癌等疾病的相关研究现状进行综述,着重讨论了F.prausnitzii作为潜在益生菌在肠道疾病中的重要作用,进而通过使用益生菌或者改变肠道内F.prausnitzii的数量达到预防或治疗肥胖、糖尿病及肠道疾病的目的。

Faecalibacterium prausnitzii is one of the symbiotic anaerobes living in mammalian gastrointesti nal tract and is also the most abundant bacterium in human gut microbiota of healthy adults. In order to provide references for the prevention and treatment of obesity, diabetes and intestinal diseases by using probiotics or changing the number of F. prausnitzii in gut, this article focused on the correlation of F. prausnitzii with obesity, diabetes, inflammatory bowel disease and colorectal cancer, especially the potential effects of F. prausnitzii as probiotics in intestinal diseases.