乳腺浸润性导管癌超声征象与ER、C-erbB-2表达的临床探讨

Ultrasonic images of invasive ductal carcinoma of breast and expression of ER and C-erbB-2:A clinical study

目的:针对乳腺浸润性导管癌患者,讨论其超声征象与ER、C-erbB-2表达的关系,为日后的临床诊断提供参考与指导。方法:选择我院于2015年5月--2016年3月收治的乳腺浸润性导管癌患者138例为研究对象。观察其超声征象与ER、C-erbB-2表达的关系,包括边缘毛刺征象、微钙化、后方回声衰减3个方面。结果:在超声征象当中,发现患者的ER阳性率为50.7%(70/138),超声显示有边缘毛刺征等患者高于不具备特征患者(P<0.05);患者的C-erbB-2表达率为29.0%(40/138),有微钙化征象者高于无微钙化征象者(P<0.05)。结论:乳腺浸润性导管癌患者,超声征象集中在边缘毛刺征象、后方声衰减征象等,可以此来预测患者的ER水平。利用微钙化征象,可有效分析患者的C-erbB-2表达水平。日后在临床诊断中,可以推广应用。

Objective：To investigate the correlation between ultrasonic images and ER and C-erbB-2 expression in patients with breast invasive ductal carcinoma, and to provide reference and guidance for future clinical diagnosis.Methods： A total of 138 patients with breast invasive ductal carcinoma, who were hospitalized in our hospital between May 2015 and March 2016, were included as the subjects in the study.The correlation between its ultrasonic images and ER and C-erbB-2 expression was determined, including the spiculated margin, microcalcification, and posterior echo attenuation.Results：The positive rate of ER was 50.7%（70/138） in the ultrasound images, and it was higher in patients with spiculated margin than that in patients without spiculated margin（P〈0.05）.The expression rate of C-erbB-2 was 29.0%（40/138）, and it was higher in patients with microcalcification than that in patients without microcalcification（P〈0.05）.Conclusion：Ultrasonic images in patients with breast invasive ductal carcinoma focus on images of spiculated margin and posterior echo attenuation, which may be used to predict the ER level.Using images of microcalcification may effectively analyze the C-erbB-2 expression level.It justifies widespread use in future clinical diagnosis.