大颗粒淋巴细胞白血病三例并文献复习

Large granular lymphocyte leukemia in three cases report and review of the literature

目的 探讨大颗粒淋巴细胞白血病（LGLL）的临床特征及诊疗方法.方法 回顾性分析3例LGLL患者的实验室检查结果及治疗方法,并复习相关文献.结果 3例患者均以重度贫血起病,病情进展缓慢,均为T大颗粒淋巴细胞白血病（T-LGLL）,免疫表型特征为CD3.＋CD4.-CD8.＋CD56.-CD57.＋,其中2例给予亚砷酸联合环孢素治疗,1例给予甲氨蝶呤、环孢素治疗,造血较前恢复.结论 LGLL是一组异质性疾病,其临床特征及预后各不相同.流式细胞术免疫表型分析及TCR基因重排等检测有利于明确诊断.

Objective To investigate the clinical characteristics and diagnosis and treatment of large granular lymphocytic leukemia （LGLL）.Methods The laboratory results and treatment in three patients with LGLL were retrospectively analyzed, and relevant literature was reviewed.Results All of 3 patients were onset with severe anemia,whose conditions progressed slowly.The diagnosis of 3 patients was T-LGLL with immunological characteristics of CD3.＋CD4.-CD8.＋CD56.-CD57.＋.Two of them were treated with arsenious acid and cyclosporine, one of them was given methotrexate and cyclosporine, Hematopoietic system recovered than before.Conclusions LGLL is a group of heterogeneous diseases with different clinical characteristic and prognosis.Flow cytometric immunopheotype and TCR gene rearrangement are helpful to diagnosis.