抗癫痫药对成人骨代谢的影响及药学监护

Bone metabolism, pharmaceutical assessment and monitoring of Adults treated with antiepileptic drug

目的:探讨抗癫痫药对成人骨代谢的影响及癫痫合并骨质疏松患者药学监护。方法:对1例癫痫合并严重骨质疏松患者的病例进行分析,探讨抗癫痫药对该患者骨代谢的影响及该患者骨质疏松的治疗。结果:对患者进行药学评估,认为患者严重骨质疏松与长期使用抗癫痫药丙戊酸钠有关,并对患者进行维生素D、钙剂补充及双膦酸盐治疗。结论:对于长期使用抗癫痫药的患者进行骨代谢相关指标监测及药学评估,适时的进行药学干预可预防及降低患者严重骨质疏松及骨折发生风险。

Objective： To explore the effect of antiepileptic drug therapy on bone metabolism, and corresponding pharmaceutical assessment and monitoring of epileptic patients with osteoporosis. Methods：One case of epileptic with osteoporosis was analyzed and explored the association between antiepileptic drugs and reduced bone mineral density.We aimed to provide references for practical management of this problem. Results and Conclusion： Epileptic patients taking prolonged therapy are at high-risk of osteoporosis, and measurement of serum calcium, alkaline phosphatase, and 25-hydroxyvitamin D are necessary. Pharmaceutical intervention and care can prevent and reduce the risk of osteoporosis and fracture in epileptic patients.