晚期糖基化终末产物及其受体与非酒精性脂肪性肝病的关系

Relationship between advanced glycation end-products and its receptor in nonalcoholic fatty liver diseases

晚期糖基化终末产物（AGE）是高血糖的标志物,能通过AGE受体（RAGE）发挥致病作用.研究发现,AGE/RAGE与非酒精性脂肪性肝病（NAFLD）的发展关系密切.AGE能增加肝脏的甘油三酯水平,促进单纯性脂肪肝（SFL）的发生,AGE/RAGE可诱导肝脏炎性反应,促进SFL向非酒精性脂肪性肝炎（NASH）发展,并能通过诱导活性氧簇的合成,活化肝脏星状细胞来引起肝纤维化.

Advanced glycation end-products （AGE） are biomarkers of hyperglycemia,the receptors for AGE （RAGE） are involved in AGE-induced pathogenesis.It has found that AGE/RAGE was closely associated with the development of nonalcoholic fatty liver diseases （NAFLD）.AGE can increase the accumulation of hepatic triglycerides and promote the occurrence of simple fatty liver （SFL）.AGE/RAGE induces hepatic inflammation and accelerates the development of SLF to nonalcoholic steatohepatitis （NASH）,and induces hepatic cirrhosis by promoting the synthesis of reactive oxygen species,activating hepatic stellate cells.