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APPL1在糖尿病及其并发症中的作用 被引量：5

Role of APPL1 in diabetes mellitus and its complications
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摘要 APPL1 （adaptor protein,phosphotyrosine interacting with PH domain and leucine zipper 1）是一种细胞内转接蛋白,可以和多种蛋白作用,介导细胞内多条信号通路.目前发现APPL1在胰岛β细胞中高度表达,与胰岛素分泌、胰岛素抵抗、糖尿病及其并发症密切相关. APPL1 （adaptor protein,phosphotyrosine interacting with PH domain and leucine zipper 1） is an intracellular adaptor protein.It interacts with a variety of proteins and functions in intracellular signaling pathways.Recently,APPL1 is found highly expressed in islet β cells,closely relating with insulin secretion,insulin resistance,diabetes and its complications.
作者 范琳玲 叶红英 王熠 Fan Linling Ye Hongying Wang Yi.(Department of Endocrinology ＆ Metabolism, Huashan Hospital, Medical College, Fudan University, Shanghai 200040, Chin)
机构地区 复旦大学附属华山医院内分泌科
出处 《国际内分泌代谢杂志》 2017年第3期199-202,共4页 International Journal of Endocrinology and Metabolism
基金 国家自然科学基金资助项目（81400844）
关键词 APPL1 脂联素 胰岛素 胰岛细胞 糖尿病 APPL1 Adiponectin Insulin Islet β cell Diabetes mellitus
分类号 R587.2 [医药卫生—内分泌]
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国际内分泌代谢杂志
2017年 第3期

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