甲状腺乳头状癌中Survivin,VEGF,EGFR的表达及临床意义分析

Expressions and Clinical Significances of Survivin, VEGF and EGFR in the Papillary Thyroid Carcinoma

目的:探讨甲状腺乳头状癌(PTC)中存活素(Survivin)、血管内皮生长因子(VEGF)、表皮生长因子受体(EGFR)的表达及临床意义。方法:选择2013年4月~2016年4月在我院收治的100例PTC患者的手术标本以及同期100例癌旁正常甲状腺组织为研究对象,采用免疫组化方法检测盒比较Survivin、VEGF、EGFR的表达在PTC及癌旁正常甲状腺组织中的表达及二者的相关性,并分析其Survivin、VEGF、EGFR的表达与PTC患者临床病理特征的相关性。结果:PTC组织中Survivin、VEGF、EGFR阳性表达率均显著高于癌旁正常甲状腺组织,差异具有统计学意义(P<0.05);Survivin、VEGF在淋巴结转移患者中的阳性表达率显著高于无淋巴结转移者(P<0.05);EGFR在女性PTC患者中的阳性表达率显著高于男性(P<0.05)。PTC组织中VEGF和Survivin、EGFR的表达无显著相关性(P>0.05),但Survivin和EGFR的表达显著相关(r=0.235,P<0.05)。结论:Survivin、VEGF、EGFR在PTC组织中表达上调,Survivin、VEGF与PTC的淋巴结转移有关,Survivin和EGFR在PTC的发生、发展过程中可能存在着协同作用。

Objective： To study the expressions and clinical significances of survivin, vascular endothelial growth factor （VEGF） and epidermal growth factor receptor（EGFR） in papillary carcinoma of thyroid （PTC）. Methods： 100 patients with PTC who were treated in our hospital from April 2013 to April 2016 were selected as the research objects and another 100 cases with normal thyroid tissues adjacent to cancer were selected as the control group. Then the expressions of EGFR, VEGF and survivin and their correlation with the pathological characteristics were analyzed. Results： The positive expressions of survivin, VEGF and EGFR in PTC tissues were higher than those of the normal thyroid tissues （P〈0.05）. The positive rates of VEGF and survivin in lymph node metastasis were higher than those of patients without lymph node metastasis （P〈0.05）. The positive expression of EGFR in female patients was higher than that of male＇s （P〈0.05）. There was no significant correlation between VEGF, Survivin and EGFR （P〉0.05）, and there was correlation between survivin and EGFR （P 〈 0.05）. Conclusion： In the occurrence and development of PTC, the expressions of survivin might be related to lymph node metastasis, and there might be a synergistic effect between survivin and EGFR, providing preliminary experimental evidence for targeted drug action in the treatment of PTC.