磁共振弥散加权成像及ADC值对鼻咽癌颅底放疗疗效的评价价值

Value of Magnetic Resonance Diffusion Weighted Imaging and ADC Values in Evaluating the Efficacy of Radiotherapy for Nasopharyngeal Carcinoma in the Basicranial

目的:探讨磁共振弥散加权成像(DWI)及表观扩散系数(ADC)值在鼻咽癌颅底放疗中的临床价值。方法:收集我院于2013年6月~2014年6月复查的40例鼻咽癌患者,分别于放疗前及放疗结束12个月以后对所有患者行常规核磁共振成像(MRI)及DWI检查,测量放疗前、后ADC值,根据影像学检查以及临床诊断结果分为复发组(n=5)及未复发组(n=35)。结果:复发组放疗前ADC值为(0.797±0.031)×10^(-3)mm^2/s,与未复发组放疗前ADC值(0.805±0.028)×10^(-3)mm^2/s比较,差异无统计学意义(P>0.05)。复发组放疗结束12个月以后ADC值为(1.097±0.091)×10^(-3)mm^2/s,与未复发组放疗结束12个月以后ADC值(1.705±0.128)×10^(-3)mm^2/s比较,差异有统计学意义(P<0.05)。结论:DWI作为一种新兴的磁共振成像技术,对于鼻咽癌颅底放疗疗效的评价具有重要价值,通过DWI对ADC值的测量,可有效的预测患者预后是否良好。

Objective： To investigate the clinical value of magnetic resonance diffusion weighted imaging （DWI） and apparent diffusion coefficient （ADC） in radiotherapy for nasopharyngeal carcinoma in the basicranial. Methods： Selected 40 cases of patients with nasopharyngeal carcinoma rechecked in our hospital from June 2013 to June 2014. Routine magnetic resonance imaging （MR/） and DWI examination were performed in all patients before and 12 months after radiotherapy, and the ADC values were measured before and after radiotherapy, according to the imaging examination and clinical diagnosis, the patients were divided into recurrence group （n=5） and non recurrence group （n=35）. Results： The ADC value of the recurrence group was （0.797 ± 0.031）×10-3nm2/s, compared with （0.805±0.028）× 10-3mm2/s in the non recurrence group before radiotherapy, the difference was not statistically significant （P〉0.05）. 12 months after radiotherapy, the ADC value of recurrence group was （1.097±0.091）× 10-3mm2/s, compared with （1.705±0.128）× 10-3 mm2/s in the non recurrence group, the difference was statistically significant （P〈0.05）. Conclusion： DWI is a new magnetic resonance imaging technology. It has important value for the evaluation of curative effect of radiotherapy for nasopharyngeal carcinoma in the basicranial, and the ADC value is effective to predict the prognosis measured by DWI.