温针联合骨疏康胶囊治疗膝关节骨性关节炎的疗效及对炎症因子的影响

Clinical Effects of Needling Warming Therapy Combined Gushukang Capsule on Patients with Knee Osteoarthritis and Its Effect on Inflammatory Factors

目的:分析温针联合骨疏康胶囊治疗膝关节骨性关节炎的疗效及对患者白细胞介素-1(IL-1)、肿瘤坏死因子(TNF-α)、基质金属蛋白(MMP-3)水平的影响。方法:以2013年1月至2016年1月新疆巴音郭楞蒙古自治州人民医院中医科收治的90例膝关节骨性关节炎患者为研究对象,并根据就诊顺序分为观察组、对照组A和对照组B,每组30例。观察组采用温针联合骨疏康胶囊治疗,对照组A仅给予温针治疗,对照组B仅给予骨疏康胶囊治疗。观察和比较三组的临床疗效、视觉模拟评分法(VAS)评分、Lysholm膝关节康复量表(LKSS)评分和症状评分及膝关节液中IL-1、TNF-α、MMP-3水平。结果:观察组的总有效显著高于对照组A和对照组B(P<0.05),而对照组A和对照组B之间比较差异无统计学意义(P>0.05)。治疗后,三组的VAS、症状评分、膝关节液中IL-1、TNF-α、MMP-3水平均较治疗前显著降低,LKSS评分较治疗前显著升高(P<0.05)。观察组的VAS、症状评分、膝关节液中IL-1、TNF-α、MMP-3水平低于对照组A和对照组B,LKSS评分高于对照组A和对照组B(P<0.05),对照组A和对照组B之间比较差异均无统计学意义(P>0.05)。结论:温针联合骨疏康胶囊治疗膝关节骨性关节炎的疗效较单用温针或骨疏康胶囊更显著,可有效改善患者的临床症状,可能与降低膝关节液中IL-1、TNF-α、MMP-3水平有关。

Objective： To investigate the clinical effects of needling wanning therapy combined with Gushukang capsule on patients with knee osteoarthritis and its effect on inflammatory factors. Methods： 90 cases of patients with knee osteoarthritis in our hospital from January 2013 from January 2016 were divided into observation group, control group A and control group B, 30 cases in each group. Patients in the observation group were treated with needling wanning therapy combined traditional Chinese medicine, patients in the con- trol group A were treated only with needling warming therapy, and patients in the control group B were treated only with traditional Chi- nese medicine. The clinical effects, VAS （visual analogue scale） scores, LKSS （Lysholm knee rehabilitation scale）scores, symptom scores and the levels of IL-1 （nterleukin-1）, TNF-ct （tumor necrosis factor-a）, MMP-3 （matrix metaloproteinase-3） of three group were com- pared. Results： The total effective rate of the observation group were significantly higher than that of the control group A and control group B（P〈0.05）, but there was no significant differences between the control group A and control group B（P〉0.05）; After treatment, the VAS scores, symptom scores and the levels ofIL-1, TNF-et, MMP-3 of the observation group were significantly lower than before treat- ment and that of the control group A and control group B （P〈0.05）, and the LKSS scores were siguificantly higher than before treatment and that of the control group A and control group B （P〈0.05）. Conclusion： Needling warming therapy combined with Gushukang capsule had better clinical effect on patients with knee osteoarthritis than needling warming therapy or Gushukang capsule alone, it could effectively improve the clinical symptoms of patients, and reduce the levels ofIL-1, TNF-α, MMP-3 in knee joint fluid.