MDSCs在恶性肿瘤中的生物学作用及其研究进展

Progress in the Research of Biological Function of MDSCs in Malignant Tumor

髓源抑制性细胞(myeloid-derived suppressor cells,MDSCs)是一群以骨髓祖细胞和未分化成熟的粒细胞、树突状细胞、巨噬细胞为代表的异质髓细胞,表达的抗原标志多样且不同于成熟髓细胞。当机体处于癌症、炎症、感染等状态时,MDSCs首先从骨髓被募集到外周并在外周被活化,一系列肿瘤来源的慢性炎症相关的因子是介导MDSCs的募集和活化的关键。MDSCs有多种方法抑制机体的获得性和天然抗肿瘤免疫,来帮助肿瘤细胞逃避机体的免疫监视和攻击,促进肿瘤发展。近年来,越来越多的研究者开始关注MDSCs与恶性肿瘤的相关性而且靶向MDSCs的肿瘤免疫治疗也见于报道。本文旨在对MDSCs在恶性肿瘤中的生物学作用及研究进展作一简要综述。

Myeloid-derived suppressor cells （MDSCs） are a heterogeneous population of immature myeloid cells, which are the precursors of macrophages and granulocyte and dendritic cells, which express various antigen markers different from other mature myeloid cells. When the body is in the state of cancer, inflammation, infection, MDSCs would be accumulated to the periphery from the bone marrow and activated, in which a series of tumor-derived factor associated with chronic inflammation is a key mediator. MDSCs has a variety of methods to suppress the body＇s acquired and natural anti-tumor immunity, which makes the tumor cells can escape the body＇s immune surveillance and attack, promoting tumor development. In recent years, more and more researchers began to pay attention to the correlation between MDSCs and malignant tumor, and the tumor immunotherapy targeting MDSCs was also reported. The purpose of this paper is to review the biological function and research progress of MDSCs in malignant tumors.