褪黑素对脑梗死的保护作用及研究进展

Research Process of Melatonin on the Protective Effects of Cerebral Infarction

脑梗死是危及生命的一种脑血管病,具有高致残率和高致死率的特点。氧化应激、炎症、钙超载和凋亡在脑梗死的二次损伤中发挥重要作用。近年来,随着医疗技术和理论的发展,人类对脑梗死的二次损伤引起的损害有了更多的认识。褪黑素主要是由是大脑松果体腺合成分泌的一种吲哚类神经内分泌激素,具有抗氧化应激、抗炎症、减轻钙离子超载和抗凋亡作用。近年来,越来越多的证据表明褪黑素可以提高脑梗死后预后,其对脑梗死后的保护作用日益引起越来越多人的关注。本文就褪黑素的生理功能和其对脑梗死后保护作用及其可能机制进行综述。

Cerebral infraction is a life-threatening disease associated with significant morbidity and mortality in cerebrovascular diseases. Oxidative stress, inflammation, calcium overload and apoptosis play key roles in the second injury of cerebral infarction. How- ever, increased interest in stroke over the past decade has improved our knowledge of the underlying mechanisms of the brain injury in cerebral infarction. Melatonin （N-acetyl-5-methoxytryptamine）, an indoleamine that is endogenously produced in the pineal gland, has the characteristic of antioxidant, anti-inflammatory, anti-apoptotic effects and reducing the overload of calcium in cells that can protect against damage following cerebral ischemic. Increasing evidence has showed that melatonin treatment improves the clinical outcome of cerebral infraction and it also attracts more and more researchers ＇attention in recent years. This review will further discuss the physiological functions ofmelatonin and provide evidence regarding the advantages of melatonin treatment for cerebral infarction.