幽门螺杆菌感染对胃溃疡患者胃蛋白酶原及胃肠动力状态的影响研究

Influence of Helicobacter pylori infection on pepsinogen and gastrointestinal motility state of patients with gastric ulcer

目的探讨幽门螺杆菌感染对胃溃疡患者胃蛋白酶原及胃肠动力状态的影响,为临床诊治提供参考依据。方法选取2015年2月-2016年9月医院收治的56例胃溃疡且幽门螺杆菌阳性患者为A组,同期56例胃溃疡且幽门螺杆菌阴性患者为B组,另选同期56名健康者为C组,比较三组胃蛋白酶原及胃肠动力状态相关指标,同时比较A组不同类型幽门螺杆菌感染患者的检测结果。结果 A组的血清胃蛋白酶原相关指标均低于B组及C组,B组则低于C组,A组胃肠动力状态相关指标均差于B组及C组,B组则差于C组,且A组不同类型幽门螺杆菌感染患者的检测结果也存在显著性差异(P均<0.05),检测结果间均有显著性差异。结论幽门螺杆菌感染对胃溃疡患者胃蛋白酶原及胃肠动力状态的不良影响较大,且幽门螺杆菌的类型对其影响也较为明显,因此,应重视对胃溃疡患者进行幽门螺杆菌的监测。

OBJECTIVE To explore the influence of Helicobacter pylori infection on pepsinogen and gastrointestinal motility state of patients with gastric ulcer so as to provide guidance for clinical diagnosis and treatment.METHODS A total of 56 gastric ulcer patients who were positive for H.pylori and were treated in the hospital from Feb 2015 to Sep 2016 were chosen as the group A,meanwhile,56 gastric ulcer patients who were negative for H.pylori were set as the group B,and 56 healthy people were chosen as the group C.The pepsinogen and gastrointestinal motility state were compared among the three groups,and the detection results were compared among the patients with different types of H.pylori infection in the group A.RESULTS The levels of serum pepsinogenrelated indexes of the group A were lower than those of the group B and the group C,and the levels of serum pepsinogen-related indexes of the group B were lower than those of the group C.The levels of gastrointestinal motility state-related indexes of the group A were worse than those of the group B and the group C,and the levels of gastrointestinal motility state-related indexes of the group B were worse than those of the group C.There was significant difference in the detection result among the patients with different types of H.pylori infection in the group A,and there was also significant between-group difference.CONCLUSION The H.pylori infection has great influence on the pepsinogen and gastrointestinal motility state of the gastric ulcer patients,and the type of H.pylori infection also has significant influence on them,therefore,it is necessary to focus on the surveillance of H.pylori for the gastric ulcer patients.