乳腺癌患者乙型肝炎病毒感染及肝功能状况研究

Prevalence of hepatitis B virus infection and liver function of breast cancer patients

目的探讨乳腺癌患者乙型肝炎病毒感染及肝功能变化情况,为临床治疗提供参考依据。方法选择医院2011年1月-2015年12月乳腺癌患者300例为乳腺癌组,并选取同期健康体检者300名为对照组,测定血清乙型肝炎病毒表面抗原(HBsAg)、乙型肝炎病毒表面抗体(HBsAb)、乙型肝炎病毒e抗原(HBeAg)、乙型肝炎病毒e抗体(HBeAb)、乙型肝炎病毒核心抗体(HBcAb)滴度及肝功能。结果乳腺癌组患者HBeAb阳性率和HBcAb阳性率明显高于对照组(P<0.05);<40岁患者中,乳腺癌组患者HBeAb阳性率和HBcAb阳性率明显高于对照组(P<0.05),乳腺癌组HBsAg滴度、HBsAb滴度、HBeAg滴度低于对照组(P<0.05),乳腺癌组谷丙转氨酶水平高于对照组(P<0.05);40~59岁患者中,乳腺癌组患者HBeAb阳性率和HBcAb阳性率明显高于对照组(P<0.05),乳腺癌组HBsAg滴度、HBeAg滴度、HBcAb滴度低于对照组(P<0.05),乳腺癌组谷丙转氨酶水平高于对照组(P<0.05);≥60岁患者中,乳腺癌组患者和对照组观察对象HBsAg阳性率、HBsAb阳性率、HBeAg阳性率、HBeAb阳性率和HBcAb阳性率比较差异无统计学意义;乳腺癌组HBeAg滴度低于对照组(P<0.05),乳腺癌组谷丙转氨酶水平高于对照组(P<0.05)。结论乙型肝炎病毒感染可能与乳腺癌有一定关系,乳腺癌患者谷丙转氨酶水平升高。

OBJECTIVE To explore the prevalence of hepatitis B virus （HBV） infections and observe the change of liver function of breast cancer patients so as to provide guidance for clinical treatment.METHODS Totally 300 patients with breast cancer who were treated in the hospital from Jan 2011 to Dec 2015 were chosen as the breast cancer group,meanwhile,300 healthy people who received physical examination were set as the control group.The titers of serum hepatitis B virus surface antigen（HBsAg）,hepatitis B virus surface antibody （HBsAb）,hepatitis B virus E antigen （HBeAg）,hepatitis B virus E antibody （HBeAb）,and hepatitis B virus core antibody （HBcAb）were determined,and the liver function was examined.RESULTS The positive rates of HBeAb and HBcAb of the breast cancer group were significantly higher than those of the control group.Among the patients aged less than 40 years old,the positive rates of HBeAb and HBcAb of the breast cancer group were significantly higher than those of the control group （P〈0.05）;the titers of HBsAg,HBsAb,and HBeAg of the breast cancer group were significantly lower than those of the control group （P〈0.05）;the alanine aminotransferase level of the breast cancer group was significantly higher than that of the control group （P〈0.05）.Among the patients aged between 40 and 59 years old,the positive rates of HBeAb and HBcAb of the breast cancer group were significantly higher than those of the control group （P〈0.05）;the titers of HBsAg,HBeAg,and HBcAb of the breast cancer group were significantly lower than those of the control group;the alanine aminotransferase level of the breast cancer group was significantly higher than that of the control group（P〈0.05）.Among the patients aged no less than 60 years old,there was no significant difference in the positive rate of HBsAg,HBsAb,HBeAg,HBeAb,or HBcAb between the breast cancer group and the control group;the HBeAg titer of the breast cancer group was significantly lower than that of the control group （P〈0.05）;the alanine aminotransferase level of the breast cancer group was significantly higher than that of the control group （P〈0.05）.CONCLUSION The HBV infection may show certain relationship with the breast cancer,and the alanine aminotransferase level of the breast cancer patients is elevated.