义乌地区非孕女性生殖道无乳链球菌的感染筛查及耐药性分析

Screening of non-pregnant women with genital tract Streptococcus agalactiae infection in Yiwu area and analysis of drug resistance

目的筛查义乌地区非孕女性生殖道无乳链球菌的感染情况,并对其进行耐药性分析,为临床治疗提供参考依据。方法选取2015年2月-2016年5月于医院就诊的非孕女性4 900例为研究对象,对调查对象生殖道进行标本采集,再进行无乳链球菌培养及药物敏感性试验,筛查义乌地区非孕女性生殖道无乳链球菌的感染情况,并进行耐药性分析。结果 4 900例非孕女性中感染无乳链球菌268例,感染率为5.5%;其中无乳链球菌检出率最高为31~40岁组,与其他年龄段相比其检出率明显升高,差异有统计学意义(P<0.05);通过对检测的阳性标本进行耐药性分析,结果显示,无乳链球菌耐药性较高的抗菌药物包括四环素、红霉素及克林霉素;未产生耐药性的抗菌药物包括头孢曲松与万古霉素,此外,无乳链球菌耐药性较低的抗菌药物还有头孢他啶、头孢噻肟、青霉素G、氨苄西林,耐药率均<2.0%。结论义乌地区非孕女性生殖道无乳链球菌的感染率较高,且31~40岁非孕女性生殖道无乳链球菌检出率最高,临床上应根据药敏结果对抗菌药物进行合理使用。

OBJECTIVE To screen the prevalence of genital tract Streptococcus agalactiae infection in non-pregnant women in Yiwu area and observe the drug resistance so as to provide guidance for clinical treatment.METHODS A total of 4 900 non-pregnant women who were treated in hospitals from Feb 2015 to May 2016 were recruited as the study objects,then the genital tract specimens were collected from the study objects for culture of S.agalactiae,the drug susceptibility testing was performed,the prevalence of genital tract Streptococcus agalactiae infection in non-pregnant women in Yiwu area was screened,and the drug resistance was observed.RESULTS Of the 4 9000 non-pregnant women,268 had S.agalactiae infection,with the infection rate 5.5 %;the isolation rate of S.agalactiae was the highest in the non-pregnant women aged between 31 and 40 years old and was significantly higher than that in the non-pregnant women of other age groups（P〈0.05）.The result of analysis of drug resistance of the positive specimens showed that the S.agalactiae strains were highly resistant to tetracycline,erythromycin,and clindamycin,however,the strains were not resistant to ceftriaxone and vancomycin,moreover,the drug resistance rate of the S.agalactiae strains to ceftazidime,cefotaxime,penicillin G,and ampicillin was less than 2.0 %.CONCLUSION The incidence rate of genital tract S.agalactiae infection is high in the non-pregnant women in Yiwu area,and the isolation rate of the S.agalactiae strains is the highest in the non-pregnant women aged between 31 and 41 years old.It is necessary for the hospital to reasonably use antibiotics based on the result of the drug susceptibility testing.