输卵管妊娠患者生殖道解脲脲原体和衣原体的感染情况分析

Prevalence of genital tract infection with Ureaplasma urealyticum and Chlamydia trachomatis in tubal pregnancy patients

目的分析输卵管妊娠患者血清、宫颈分泌物、输卵管组织中解脲脲原体和沙眼衣原体的感染情况,探讨输卵管妊娠与生殖道解脲脲原体和沙眼衣原体的相关性。方法选取2014年1月-2015年12月医院妇产科输卵管妊娠行腹腔镜下输卵管切除术患者70例为输卵管妊娠组,另选妇科良性病变行腹腔镜下附件切除术或者输卵管切除术患者70例为对照组,检测血清解脲脲原体和沙眼衣原体抗体、宫颈分泌物和输卵管组织中解脲脲原体和沙眼衣原体DNA;比较两组患者血清、宫颈分泌物和标本中沙眼衣原体、解脲脲原体、解脲脲原体+沙眼衣原体的阳性率。结果输卵管妊娠组血清、宫颈分泌物和标本中沙眼衣原体阳性率(31.4%、37.1%、24.3%)均高于对照组(4.3%、5.7%、2.9%),两组比较差异有统计学意义(P<0.05);输卵管妊娠组血清、宫颈分泌物和标本中解脲脲原体阳性率(41.4%、40.4%、31.4%)均高于对照组(11.4%、8.6%、2.9%),两组比较差异有统计学意义(P<0.05);输卵管妊娠组血清、宫颈分泌物和标本中解脲脲原体+沙眼衣原体阳性率(20.0%、12.9%、18.6%)均高于对照组(4.3%、1.4%、1.4%),两组比较差异有统计学意义(P<0.05)。结论输卵管妊娠患者血清、宫颈分泌物、输卵管组织中解脲脲原体和沙眼衣原体阳性率升高,输卵管妊娠和生殖道解脲脲原体和沙眼衣原体感染关系密切。

OBJECTIVE To investigate the prevalence of Ureaplasma urealyticum and Chlamydia trachomatis infections in serum,cervical secretions,and tubal tissues of tubal pregnancy patients and analyze the relationship between the tubal pregnancy and the genital tract U.urealyticum and C.trachomatis.METHODS A total of 70 tubal pregnancy patients who underwent laparoscopic salpingectomy in department of gynecology and obstetrics from Jan 2014 to Dec 2015 were chosen as the tubal pregnancy group,while 70 patients with gynecological benign lesions who underwent laparoscopic appendectomy or salpingectomy were set as the control group.The U.urealyticum and C.trachomatis antibodies in serum and U.ureatyticum and C.trachomatis DNA in cervical secretions and tubal tissues were detected.The positive rates of U.urealyticum,C.trachormatis,and U.urealyticum plus C.trachomatis in serum,cervical secretions and specimens were observed and compared between the two groups of patients.RESULTS The positive rates of C.trachomatis in serum,cervical secrestions and specimens of the tunbal pregnancy group were respectively 31.4%,37.1%,and 24.3%,higher than 4.3%,5.7%,and 2.9% of the control group,and there was significant difference between the two groups （P〈0.05）;the positive rates of U.urealyticum in serum,cervical secrestions and specimens of the tunbal pregnancy group were respectively 41.4%,40.4%,and 31.4%,higher than 11.4%,8.6%,and 2.9% of the control group,and there was significant difference between the two groups （P〈0.05）;the positive rates of U.urealyticum plus C.trachomatis in serum,cervical secrestions and specimens of the tunbal pregnancy group were respectively 20.0%,12.9%,and 18.6%,higher than 4.3 %,1.4 %,and 1.4 % of the control group,and there was significant difference between the two groups （P〈0.05）.CONCLUSION The positive rates of U.urealyticum and C.trachomatis are increased in the serum,cervical secretions,and tubal tissues of the tubal pregnancy patients.The tubal pregnancy is closely associated with the genital tract infection with U.urealyticum and C.trachomatis.