MR mDIXON-Quant技术精确测量2型糖尿病合并非酒精性脂肪肝患者的肝脏脂肪含量

Application of MR mDIXON-quant technique in accurate quantification of liver fat content in type 2 diabetic patients with nonalcoholic fatty liver disease

目的:探讨MR mDixon-Quant技术在精确测量2型糖尿病合并非酒精性脂肪肝患者肝脏脂肪含量中的应用价值。方法:共纳入98例研究对象,其中糖尿病组(患有2型糖尿病)男33例,女16例,对照组(无2型糖尿病)男33例,女16例。所有研究对象均行肝脏3.0T MR mDixon-Quant检查,并测量肝脏脂肪含量(%)。以脂肪含量>5%作为脂肪肝的诊断标准。比较两组非酒精性脂肪肝检出率的差异。结果:糖尿病组肝脏脂肪含量中位数为5.5%(25分位值3.8%,75分位值11.0%),对照组肝脏脂肪含量中位数为3.7%(25分位值2.5%,75分位值5.7%)。糖尿病组脂肪肝总检出率为59.2%,对照组为28.6%。在男性研究对象中,糖尿病组脂肪肝检出率为63.6%(21/33),高于对照组(30.3%,10/33),差异有统计学意义(P<0.05);在女性研究对象中,糖尿病组脂肪肝检出率为50.0%(8/16),高于对照组(25.0%,4/16),但差异无统计学意义(P>0.05)。结论:采用MR mDixon-Quant技术可简便、精确测量2型糖尿病合并非酒精性脂肪肝患者的肝脏脂肪含量,可为疾病的筛查、诊断和治疗效果评估提供重要参考。

Objective：To investigate the application value of MR mDIXON-quant technique in accurate quantification of liver fat content in type 2 diabetic patients with non-alcoholic fatty liver disease （NAFLD）. Methods： 98 subjects were studied in this research,including 33 males and 16 females in diabetic group,33 males and 16 females in control group （non- diabetic group）. All subjects underwent liver MR mDIXON-quant imaging,and liver fat content was measured on MR work- station. The difference of detection rate of non-alcoholic fatty liver was compared between the two groups. Results：The me- dian fat content of liver was 5.50//00 （first quartile 3.8%, third quartile 11.0%） in diabetic group and 3.7% （first quartile 2.5%,third quartile 5. 7%） in control group. The total detection rate of fatty liver was 59. 2% in diabetic group, and 30.3% in control group. In the male subjects,the detection rate of fatty liver in diabetic group （63.6% ,21/33） was higher than that in control group （30.3 %, 10/33）, and the difference was statistically significant. In female subjects, the detection rate of fatty liver in diabetic group （50% ,8/16） was higher than that in control group （25% ,4/16） ,and the difference was not statistically significant. Conclusion： Quantification of liver fat content by MR mDIXON-quant technique was convenient and accurate,and it may provide important reference for assessment of screening,diagnosis and therapeutic effect of type 2 diabetic patients with NAFLD.