西安地区妊娠期女性血清维生素A、E水平分析

Analysis of serum levels of vitamin A and E of pregnant women in Xi'an region

目的了解西安地区妊娠期女性血清维生素A、E水平现状,评价妊娠期女性维生素A、E的营养状况,指导女性妊娠期科学合理补充维生素,保证母婴健康安全。方法收集2016年6~8月西安地区妊娠早、中、晚期女性血清样本497份,采用反相高效液相色谱法定量检测血清维生素A、E水平。结果妊娠早、中、晚期女性血清维生素A检测结果依次为(0.442±0.091)mg/L、(0.445±0.097)mg/L、(0.451±0.091)mg/L,总体异常率为7.04%,主要表现为维生素A缺乏(5.23%),妊娠晚期缺乏率(5.81%)大于妊娠早期(4.92%);妊娠早、中、晚期血清维生素E检测结果依次为(10.791±2.33)mg/L、(13.469±3.35)mg/L、(14.851±4.05)mg/L,总体异常率5.26%,均为维生素E过量,孕早期女性维生素E水平均正常,随着孕周的增加,维生素E异常率也逐渐增加,妊娠中期异常率达5.00%,妊娠晚期最高达9.30%。结论妊娠各期女性血清维生素A、E水平分布有差异,维生素A异常以缺乏为主,维生素E异常均为过量,因此密切关注妊娠期女性血清维生素A、E水平状况,科学合理补充,对保证孕期母婴健康安全有重要作用。

Objective To investigate the status of serum vitamin A and E in pregnant women in Xi’an and evaluate the nutritional status of vitamin A and E in pregnant women, which can be used to guide the scientific and reasonable supplementation of vitamin for pregnant women, and to ensure the health and safety of mothers and infants.Methods A total of 497 female serum samples from Xi’an were collected from June to August in 2016. The serum levels of vitamins A and E were determined by reversed-phase high performance liquid chromatography（RP-HPLC）. Results The levels of serum vitamin A were respectively（0.442±0.091） mg/L,（0.445±0.097） mg/L,（0.451±0.091） mg/L in early, middle and late pregnancy, with the total abnormal rate of 7.04%; the main abnormality was the lack of vitamin A（5.23%）, and the lack rate of vitamin A in the late pregnancy was 5.81%, which were higher than 4.92% in the early pregnancy. The levels of serum Vitamin E in the early, middle and late pregnancy were respectively（10.791 ± 2.33） mg/L,（13.469±3.35） mg/L,（14.851±4.05） mg/L, with the overall abnormal rate of 5.26%; all the abnormality was excessive vitamin E; the vitamin E level was normal in early pregnancy, and vitamin E abnormal rate was gradually increased with the increase in gestational age from 5.00% in the mid pregnancy up to 9.30% in late pregnancy. Conclusion The levels of vitamin A and E of women in different stages of pregnancy are different. The abnormalities are mainly the lack of vitamin A and excessive vitamin E. To pay close attention to the status of serum vitamin A and E and guide the scientific and reasonable supplementation of vitamin for pregnant women have the important role in ensuring the health and safety of mothers and infants.