多功能电离子联合ALA-PDT及干扰素治疗宫颈尖锐湿疣疗效评价

Efficacy of electrocauterization combined 5-aminolevulinic acid photodynamic therapy and interferon injection in the treatment of cervical condyloma acuminatum

目的:评价多功能电离子联合5-氨基酮戊酸光动力及重组人干扰素肌肉注射治疗宫颈尖锐湿疣的疗效。方法:将240例宫颈尖锐湿疣患者随机分为4组。A组多功能电离子烧灼治疗后行ALA-PDT治疗,每周1次及重组人干扰素50μg肌肉注射,每周3次,连续4周。B组电离子烧灼后行ALA-PDT治疗,每周1次,共4次;C组多功能电离子烧灼后肌注重组人干扰素,每周3次,连续4周;D组仅使用多功能电离子烧灼。所有患者末次治疗结束后每月复诊1次,连续3次。并于末次治疗结束后的第4、8和12周进行复发率评估。结果:共189例患者完成治疗和随访。随访3个月后,A、B、C、D各组患者痊愈率分别为96.08%,83.67%,81.25%及53.66%,各组HPV清除率分别为74.51%,53.06%,50.00%及12.20%。结论:多功能电离子联合5-氨基酮戊酸光动力及重组人干扰素肌肉注射治疗宫颈尖锐湿疣的疗效满意。

Objective： To assess the efficacy of electrocauterization combined 5-aminolevulinic acid photo- dynamic therapy and interferon injection in the treatment of cervical condyloma acuminatum （CA）. Methods： Two hundred and forty patients with cervical CA were divided into 4 groups randomly. All the patients were treated with electrocauterization to remove the lesions and those were given additional 5-aminolevulinic acid photodynamic therapy immediately once a week and interferon injection, 3 times a week for 4 weeks in group A, 5-aminolevulinic acid photodynamic therapy in the group B, interferon injection in the group C. All the patients were followed up for 3 months after the last treatment. Results： One hundred and eithty-nine patients completed the treatment and follow-ups. The cure rates were 96.08%, 83.67%, 81.25% and 53.66% and the clearance of HPV were 74.51%, 53.06%, 50.00% and 12.20% in the group A, B, C and D, respectively. Conclusion： Electrocauterization combined 5-aminolevulinic acid photodynamic therapy and interferon injection is effective in the treatment of cervical CA.