红宝石点阵激光联合强脉冲光治疗黄褐斑102例疗效评价

Assessment of therapeutic efficacy of ruby dot matrix laser combined with intense pulsed light in the treatment of 102 patients with melasma

目的:评价红宝石点阵激光联合强脉冲激光治疗黄褐斑临床疗效及安全性。方法:102例黄褐斑患者给予Q开关红宝石点阵激光治疗,能量密度2.5~3.5 J/cm2,2周后,行强脉冲光治疗。每4周治疗1次,共4次。治疗结束前后对患者进行黄褐斑皮损面积和严重程度指数(MASI)评分,记录复发情况及不良反应。治疗结束后6个月随访判定结果。结果:痊愈5例(4.90%),显效69例(67.65%),好转26例(25.49%),无效2例(1.96%),总有效率72.55%。未见明显不良反应。结论:红宝石点阵激光联合强脉冲光治疗黄褐斑安全、有效。

Objective： To assess the efficacy and safety of ruby dot matrix laser combined with intense pulsed light in the treatment of melasma. Methods： One hundred and two patients with melasma were firstly treated with ruby dot matrix laser （ energy density of 2.5 -3.5 J/cm2 ） and followed by intense pulsed light after 2 weeks. The treatment was repeated every 4 weeks for 4 times. The severity and the area of melasma were assessed by melisma area severity index （MASI）. The recurrence and adverse reaction were also assessed. The therapeutic efficacy was assessed in 6 months after the end of the treatment. Results： Five patients （4.90%） were cured, 69 patients （67.65%） improved remarkably, 26 patients （25.49%） improved and 2 patients were not effective. There were no side effects in all the patients. Conclusion： Ruby dot matrix laser combined with intense pulsed light is safe and effective in the treatment of melasma.