急性ST段抬高型心肌梗塞不同时间窗溶栓疗效观察

The effect of thrombolytic therapy in different time on myocardial infarction patients with acute ST-segment elevation

目的研究ST段抬高型心肌梗塞(ST-segment elevation myocardial infarction,STEMI)患者发病后不同时间窗溶栓治疗对冠脉再通影响。方法对2009年1月-2016年9月在泽普县人民医院住院的125例STEMI接受溶栓治疗患者,根据发病后不同时间窗溶栓分成≤3 h,3~6 h,6~12 h三组,比较三组血管再通率与血管再通所需的时间差异。结果三组患者血管再通率分别为90.9%,80.9%,59.7%,差异有显著性(P<0.05);血管再通所需时间分别为(46.6±31.1)min、(77.1±35.7)min、(89.2±39.5)min,三组间差异有显著性(P<0.05)。结论 STEMI溶栓治疗的获益与溶栓开始的时间密切相关,溶栓越早血管再通率越高,血管再通所需时间越短。

Objective To study the effect of thrombolytic therapy in different time window on the coronary artery recanalization for patients with acute ST-segment elevation myocardial infarction. Methods 125 patients hospitalized in our department and received STEMI thrombolytie therapy from January 2009 to September 2016 were collected. They were divided into three groups according to the different thrombolysis time window such as 3 h, 3 - 6 h and 6- 12 h Coronary artery recanalization rate and the time required for reeanalization between three groups were compared. Results The coronary artery recanalization rate in three groups were 90.9%, 80.9%, 59.7% respectively, there were significant differences between three groups （P〈0.05） ; The time required for recanalization were （46.6 ± 31.1 ）minutes, （77.1± 35.7）minutes, （89.2 ±39.5）minutes respectively, and there were significant differences between three groups （P〈0.05）. Conclusion The effect of STEMI thrombolytie therapy is closely related to the start treating time, the earlier time when patients were treated with thrombolytic therapy is, the higher vascular recanalization rate can get and the shorter time for recanalization will be required.