摘要
目的探讨运用多层螺旋cT对肝细胞癌(HCC)进行血流灌注成像检查时的参数变化特征,并分析其与病理学特征的相关性。方法选取43例HCC患者作为观察对象,于手术前均接受多层螺旋CT灌注成像检查,分别测量并记录癌组织以及正常肝组织的灌注成像参数:门静脉灌注量(HPP)、肝动脉灌注量(HAP)、肝动脉灌注指数(HAI),并与术后相应组织标本的病理学检查结果[微血管密度(MVD)和病理分级]进行比较分析。结果与正常肝组织比较,癌组织的HAP、HAI以及MVD均明显增高,而癌组织的HPP明显下降,差异均有统计学意义(P〈0.05);癌组织的HAP、HAI分别与MVD呈正相关;高分化癌HAP、HAI〈中分化癌HAP、HAI小于低分化癌的HAP、HAI,差异具有统计学意义(P均〈0.05);高分化癌HPP〉中分化癌HPP〉低分化癌HPP,差异具有统计学意义(P均〈0.05)。结论多层螺旋CT灌注成像检查能定量分析HCC的血流灌注成像参数特征,为临床对HCC的正确诊断、病理分级、治疗决策以及预后评估提供参考依据。
Objective To study the characteristics of multilayer spiral computed tomography ( MSCT ) perfusion imaging in hepatoceUular carcinoma ( HCC ) , and its correlation with pathology. Methods 43 patients who underwent tumor resection surgery in our hospital were selected as the research objects during 2014-09 to 2016-02.All patients were examined by MSCT perfusion imaging before surgery. The perfusion imaging parameters of carcinoma tissues and normal liver tissue were measured and recorded: hepatic portal perfusinn ( HPP ) , hepatic artery perfusion ( HAP ) , hepatic arterial perfusion index ( HA1 ) and compared with the pathologic results of postoperative tissue samples: microvessel density ( MVD ) and pathological classification. Results Compared with normal liver tissue, HAP, HAl and MVD of cancer tissue were significantly increased, and HPP was significantly reduced, difference had significant statistical significance (P〈0.05) ; HAP, HAI of cancers were positively correlated with MVD; HAP, HAI in high differentiation〈 HAP, HAI in middle differentiation〈 HAP, HAI in low differentiation, difference had significant statistical significance ( P〈0.05 ) ;HPP in high differentiation 〉HPP in middle differentiation 〉HPP in low differentiation, difference had significant statistical significance (P〈0.05) . Conclusion MSCT perfusion imaging can quantitative analysis of the characteristics of perfusion imaging parameters in HCC and provide references for clinical diagnosis, pathological classification, treatment and prognostic evaluation.
出处
《浙江临床医学》
2017年第6期1119-1120,共2页
Zhejiang Clinical Medical Journal
关键词
肝细胞癌螺旋CT
血流灌注
成像
微血管密度
病理分级
Hepatocellular carcinoma Spiral CT Perfusion Imaging Microvessel density Pathology classification