失语症复述功能恢复病例报告

A Case Report of Aphasia Patient with Repetition Restoration

目的:探讨失语症患者复述功能恢复与脑功能连接改变的相关性。方法:收集失语症患者1例,采用言语康复治疗,每天40 min,每周5次,共计治疗4个月。治疗前后完成汉语失语成套检查评估及静息态功能磁共振检查,选择左侧Broca区、顶下角回、Wernicke区作为感兴趣区,观察治疗前后语言功能的改变及3个脑区间功能连接改变。结果:治疗4个月后,患者复述功能明显改善,其中词复述改善程度较大,而句子复述不明显,左侧Broca区与Wernicke区功能连接系数明显增加,Wernicke区与顶下角回连接系数则是从负相关到正相关转变。结论:失语症患者词复述的恢复可能与左侧大脑半球Broca区与Wernicke区、顶下角回与Wernicke区的功能连接增强相关。

Objective：To explore the correlation between the restoration of repetition and the functional connectivity alternation in the brain of aphasia patients. Methods：An aphasia patient treated with speech rehabilitation approach was evaluated with aphasia battery of Chinese（ABC） and required the resting-state f MRI before and after the treatment. The Broca area, angular gyrus and Wernicke area in the left hemisphere were choosed as the region of interest（ROI）, the change of language function was observed, and the correlation coefficient of functional connectivity between three ROIs were calculated. Results：After speech therapy, the word repetition score was obviously increased, but the sentence repetition score was not significantly improved. The correlation coefficient of functional connectivity between Broca area and Wernicke area was obviously increased after speech therapy. The correlation between Wernicke area and angular gyrus switched from negative correlation to positive correlation. Conclusion：The restoration of word repetition may related to the strengthen of functional connectivity of Broca-Wernicke pathway and angular-Wernicke pathway in the left hemisphere.