冠状动脉粥样硬化血管影像学进展

Intravascular imaging progress in coronary atherosclerotic disease

大多数威胁生命的冠状动脉(冠脉)粥样硬化的不良后果是由冠脉斑块破裂和急性血栓形成引起的。随着影像学技术的进展,现在的成像方式能够提供高风险斑块的特征,预测不良心血管事件的发生,改善药物治疗策略和结果。本文主要讨论可识别高风险斑块的影像学技术,包括计算机断层扫描(CT)、磁共振成像(MRI)、虚拟组织学血管内超声(VH-IVUS)、近红外光谱学(NIRS)和冠脉血管镜,及其对未来不良心血管事件的预测作用,并总结这些成像技术的优势与局限性。

Most of ischemic and life-threatening coronary events result from coronary atherosclerotic plaque rupture and acute coronary thrombosis. Along with the developing of imaging technology, recent advances, in ima ging modalities have contributed to visualizing atherosclerotic plaques and defining lesion charactensttcs in vlvo. This innovation has been applied to refining revascularization procedure, assessment of anti-atherosclerotic drug efficacy and the detection of high-risk plaques. As such, intravascular imaging plays an important role in further improvement of cardiovascular outcomes in patients with coronary artery disease. The current article reviews available intravascular imaging modalities with regard to its method, advantage and disadvantage, including multi-de rector-row computed tomography （MDCT）, magnetic resonance imaging（MRI）, virtuaI histology intravascular ultrasound （VH-IVUS）, Optical coherence tomography（OCT）, near-infrared spectroscopy（NIRS） and intracoronary coronary