CPAP治疗对阻塞性睡眠低通气综合征患者导管消融术后心房颤动复发率影响的Meta分析

Effects of CPAP treatment on AF recurrence in patients with obstructive sleep hypopnea syndrome after catheter ablation:A Meta analysis

目的:系统评价持续气道正压通气(CPAP)对阻塞性睡眠低通气综合征(OSA)患者经导管消融术后心房颤动(AF)复发率的影响。方法:计算机检索PubMed、MEDILINE、EMBASE、Cochrane library、知网、万方等数据库,检索时限从建库到2016年10月。严格按照纳入和排除标准筛选文献并提取数据,评价纳入研究的质量后,采用Stata 14软件进行Meta分析。结果:共纳入6篇队列研究,共计1 044例OSA合并AF患者。Meta分析结果显示:CPAP治疗后OSA患者导管消融术后AF的复发率显著低于对照组(RR=0.68,95%CI:0.58~0.79,I2=0,P=0.911)。结论:CPAP治疗可有效降低OSA患者导管消融术后AF的复发率,提示临床医生在诊治OSA合并AF患者过程中可以考虑使用CPAP进行治疗。

Objective：To systematically evaluate the effect of continuous positive airway pressure（CPAP） on atrial fibrillation （AF） recurrence rate in patients with obstructive sleep hypopnea syndrome （OSA） after catheter ablation. Method.. The database was retrieved from PubMed, Medline, EMBASE, Cochrane, library, CNK1 and Wanfang from inception to October, 2016. The literature was screened in strict accordance with inclusion and ex clusion criteria. Stata14 software was used for Meta analysis. Result： Six cohort studies involving 1 044 patients with OSA combined with AF were included. Meta analysis results showed that the recurrence rate of AF after CPAP treatment was significantly lower than that in control group （RR=0.68, 95%CI：0. 58--0. 79, 12 =0, P= 0.911）. Conclusion： CPAP can effectively reduce the recurrence rate of AF after catheter ablation in patients with OSA.