肝癌肿瘤微环境中非癌细胞成分的研究进展与介入治疗展望

Research progresses on non-cancer-cell component of tumor microenvironment in hepatocellular carcinoma and prospect of interventional therapy

肝癌肿瘤微环境中的非癌细胞成分,因其基因组的相对稳定性而受到关注。本文从肿瘤微环境的组成及其特点、肝癌肿瘤微环境的组成出发,对肝癌肿瘤微环境中非癌细胞成分的3个研究新的热点(外泌体、趋化因子及无生物活性条件的局部调节)进行综述,并对其在介入治疗方面的应用进行展望。

The non-cancer-cell component of the tumor microenvironment in hepatocellular carcinoma （HCC） has drawn the attention of the researchers because of its relative stability of the genome. The composition and characteristics of the tumor microenvironment and the composition of the tumor microenvironment in hepatocellular carcinoma were introduced in this article. Besides, the recent studies about the non-cancer-cell component of the tumor microenvironment in HCC were reviewed from three aspects：The exosomes, the chemokines and the local conditions without biological activity. The application of non-cancer-cell in interventional treatment in the future was also discussed.