摘要
免疫耐受是T及B淋巴细胞对抗原的特异不应答或负应答表现。按形成时期的不同,免疫耐受可分为中枢耐受和外周耐受。HBV感染后机体对HBV免疫耐受是慢性HBV感染的主要原因。简要介绍了HBe Ag、树突状细胞的功能缺陷、细胞毒性T淋巴细胞低应答、辅助性T淋巴细胞及细胞因子、HBV基因型及基因组的变异、宿主基因多态性在慢性HBV感染免疫耐受形成中的作用及相关研究进展。
Immune tolerance refers to the specific non - response or negative response ofT and B lymphocytes to antigens. According to the period of formation, immune tolerance can be classified into central tolerance and peripheral tolerance. Immune tolerance to hepatitis B virus (HBV) after HBV infection is considered a major cause of chronic HBV infection. This article briefly reviews the rotes of HBeAg, functional defects of dendritic cells, low response of cytotoxic T lymphocytes, T helper cells and cytokines, variations of HBV genotype and genome, and host gene polymorphisms in the development of immune tolerance in chronic HBV infection, as well as related research advances.
出处
《临床肝胆病杂志》
CAS
2017年第5期949-953,共5页
Journal of Clinical Hepatology
基金
国家自然科学基金资助项目(81170393)