人胎盘片对多囊卵巢综合征氯米芬促排卵周期子宫内膜容受性的影响

Effect of Human Placenta Tablets on Endometrial Receptivity of Women with Polycystic Ovary Syndrome During Clomiphene Citrate Ovulation Cycle

目的:观察人胎盘片在多囊卵巢综合征(PCOS)患者氯米芬(CC)促排卵治疗中对子宫内膜容受性的影响。方法:80例进行CC促排卵治疗的PCOS患者被随机分为两组,其中40例予以氯米芬+人胎盘片组治疗为试验组,另40例予以氯米芬+戊酸雌二醇组为对照组。治疗后比较两组患者的HCG日的子宫内膜厚度、类型以及妊娠结局。结果:实验组内膜厚度、HCG日A型内膜比例以及临床妊娠率均高于对照组,流产率低于对照组(P<0.05)。结论:人胎盘片能有效改善PCOS患者CC促排卵周期的子宫内膜容受性,效果优于戊酸雌二醇,且子代安全性更好。

Objective： To observe the influence of human placenta tablets on endometrial receptivity of women with polycystic ovary syndrome （PCOS） during clomiphene citrate （CC） ovulation cycle.Methods：80 PCOS patients who were receiving CC ovulation induction therapy were randomly divided into two groups.40 cases in study group were given CC and human placenta tablets treatment,and the other 40 cases in control group were given CC combined with estradiol valerate.Then the endometrial thickness, type on HCG day and the result of pregnancy were compared after treatment. Results： The endometrial thickness, proportion of A type on HCG day and the clinical pregnancy rate of study group were better those of control group（P 〈0.05）. The rate of abortion of stduy group was lower then that of control group （P〈0.05）.Conclusion：The human placenta tablets can improve endometrial receptivity of women with polycystie ovary syndrome （PCOS） during clomiphene citrate （CC） ovulation cycle.The effect of human placenta tablets is better than that of estradiol valerate,and is more secure for future generations.